UniProt Accession

 CMLO2_MOUSE; Q8CHQ9; Q8C7E5; Q9JIY9 

Genbank Protein ID

 AF163315; AK050449; BC039773 

Genbank Nucleotide ID

 AAF80484.1; BAC34261.1; AAH39773.1 

Protein Name

 Probable N-acetyltransferase CML2 

Protein Synonyms/Alias

 Camello-like protein 2 

Gene Name

 Cml2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
26	ELFSSGMKELIPAAI	ubiquitination	[1]
88	SCRNYVAKSLQADLA	ubiquitination	[1]
134	KDPPLGKKQMQLFRL	ubiquitination	[1]
154	HRGQGIAKALVRTVL	ubiquitination	[1]
204	QYFVSISKKLMGLSI	acetylation	[2, 3]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 

Functional Description

 May play a role in regulation of gastrulation. 

Sequence Annotation

 DOMAIN 69 212 N-acetyltransferase.  

Keyword

 Acyltransferase; Complete proteome; Developmental protein; Gastrulation; Membrane; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 238 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; ISA:MGI.
 GO:0005794; C:Golgi apparatus; ISA:MGI.
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0008080; F:N-acetyltransferase activity; NAS:UniProtKB.
 GO:0001702; P:gastrulation with mouth forming second; NAS:UniProtKB.
 GO:0007162; P:negative regulation of cell adhesion; ISA:MGI. 

Interpro

 IPR016181; Acyl_CoA_acyltransferase.
 IPR000182; GNAT_dom. 

Pfam

 PF00583; Acetyltransf_1 

SMART

  

PROSITE

 PS51186; GNAT 

PRINTS