| Tag | Content |
|---|
| CPLM ID | CPLM-006221 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1 |
Protein Synonyms/Alias | Protein OSD1; Tat-binding homolog 11; Yeast mitochondrial escape protein 1 |
Gene Name | YME1 |
Gene Synonyms/Alias | OSD1; YTA11; YPR024W; YP9367.04 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 517 | HFEWAKDKILMGAER | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Catalytic subunit of the mitochondrial inner membrane i- AAA protease supercomplex required for mitochondrial inner membrane protein turnover. The protease is probably ATP-dependent. Important to maintain the integrity of the mitochondrial compartment. Required both for the degradation of unassembled subunit 2 of cytochrome c oxidase (COX2) and for efficient assembly of mitochondrial respiratory chain. Binds unfolded substrates in an ATPase-independent manner; binding of folded COX2, a physiological substrate, requires an active ATPase but when COX2 is destabilized an active ATPase is no longer necessary. |
Sequence Annotation | NP_BIND 321 328 ATP (Potential).
ACT_SITE 541 541 By similarity.
METAL 540 540 Zinc; catalytic (By similarity).
METAL 544 544 Zinc; catalytic (By similarity).
METAL 618 618 Zinc; catalytic (By similarity). |
Keyword | ATP-binding; Complete proteome; Hydrolase; Membrane; Metal-binding; Metalloprotease; Mitochondrion; Mitochondrion inner membrane; Nucleotide-binding; Protease; Reference proteome; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 747 AA |
Protein Sequence | MNVSKILVSP TVTTNVLRIF APRLPQIGAS LLVQKKWALR SKKFYRFYSE KNSGEMPPKK 60
EADSSGKASN KSTISSIDNS QPPPPSNTND KTKQANVAVS HAMLATREQE ANKDLTSPDA 120
QAAFYKLLLQ SNYPQYVVSR FETPGIASSP ECMELYMEAL QRIGRHSEAD AVRQNLLTAS 180
SAGAVNPSLA SSSSNQSGYH GNFPSMYSPL YGSRKEPLHV VVSESTFTVV SRWVKWLLVF 240
GILTYSFSEG FKYITENTTL LKSSEVADKS VDVAKTNVKF DDVCGCDEAR AELEEIVDFL 300
KDPTKYESLG GKLPKGVLLT GPPGTGKTLL ARATAGEAGV DFFFMSGSEF DEVYVGVGAK 360
RIRDLFAQAR SRAPAIIFID ELDAIGGKRN PKDQAYAKQT LNQLLVELDG FSQTSGIIII 420
GATNFPEALD KALTRPGRFD KVVNVDLPDV RGRADILKHH MKKITLADNV DPTIIARGTP 480
GLSGAELANL VNQAAVYACQ KNAVSVDMSH FEWAKDKILM GAERKTMVLT DAARKATAFH 540
EAGHAIMAKY TNGATPLYKA TILPRGRALG ITFQLPEMDK VDITKRECQA RLDVCMGGKI 600
AEELIYGKDN TTSGCGSDLQ SATGTARAMV TQYGMSDDVG PVNLSENWES WSNKIRDIAD 660
NEVIELLKDS EERARRLLTK KNVELHRLAQ GLIEYETLDA HEIEQVCKGE KLDKLKTSTN 720
TVVEGPDSDE RKDIGDDKPK IPTMLNA 747 |
Gene Ontology | GO:0031942; C:i-AAA complex; IDA:SGD. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004176; F:ATP-dependent peptidase activity; IMP:SGD. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004222; F:metalloendopeptidase activity; IEA:InterPro. GO:0006515; P:misfolded or incompletely synthesized protein catabolic process; IMP:SGD. GO:0006457; P:protein folding; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |