CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012562
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synaptonemal complex protein 1 
Protein Synonyms/Alias
 SCP-1; Cancer/testis antigen 8; CT8 
Gene Name
 SYCP1 
Gene Synonyms/Alias
 SCP1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
295LLEESRDKVNQLEEKubiquitination[1]
684NLLEEVEKAKVIADEacetylation[2]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. 
Sequence Annotation
 MOTIF 117 120 Nuclear localization signal (Potential).
 MOTIF 679 682 Nuclear localization signal (Potential).
 MOTIF 880 883 Nuclear localization signal (Potential).
 CROSSLNK 295 295 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Cell cycle; Cell division; Chromosome; Coiled coil; Complete proteome; DNA-binding; Isopeptide bond; Meiosis; Nucleus; Polymorphism; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 976 AA 
Protein Sequence
MEKQKPFALF VPPRSSSSQV SAVKPQTLGG DSTFFKSFNK CTEDDFEFPF AKTNLSKNGE 60
NIDSDPALQK VNFLPVLEQV GNSDCHYQEG LKDSDLENSE GLSRVYSKLY KEAEKIKKWK 120
VSTEAELRQK ESKLQENRKI IEAQRKAIQE LQFGNEKVSL KLEEGIQENK DLIKENNATR 180
HLCNLLKETC ARSAEKTKKY EYEREETRQV YMDLNNNIEK MITAFEELRV QAENSRLEMH 240
FKLKEDYEKI QHLEQEYKKE INDKEKQVSL LLIQITEKEN KMKDLTFLLE ESRDKVNQLE 300
EKTKLQSENL KQSIEKQHHL TKELEDIKVS LQRSVSTQKA LEEDLQIATK TICQLTEEKE 360
TQMEESNKAR AAHSFVVTEF ETTVCSLEEL LRTEQQRLEK NEDQLKILTM ELQKKSSELE 420
EMTKLTNNKE VELEELKKVL GEKETLLYEN KQFEKIAEEL KGTEQELIGL LQAREKEVHD 480
LEIQLTAITT SEQYYSKEVK DLKTELENEK LKNTELTSHC NKLSLENKEL TQETSDMTLE 540
LKNQQEDINN NKKQEERMLK QIENLQETET QLRNELEYVR EELKQKRDEV KCKLDKSEEN 600
CNNLRKQVEN KNKYIEELQQ ENKALKKKGT AESKQLNVYE IKVNKLELEL ESAKQKFGEI 660
TDTYQKEIED KKISEENLLE EVEKAKVIAD EAVKLQKEID KRCQHKIAEM VALMEKHKHQ 720
YDKIIEERDS ELGLYKSKEQ EQSSLRASLE IELSNLKAEL LSVKKQLEIE REEKEKLKRE 780
AKENTATLKE KKDKKTQTFL LETPEIYWKL DSKAVPSQTV SRNFTSVDHG ISKDKRDYLW 840
TSAKNTLSTP LPKAYTVKTP TKPKLQQREN LNIPIEESKK KRKMAFEFDI NSDSSETTDL 900
LSMVSEEETL KTLYRNNNPP ASHLCVKTPK KAPSSLTTPG STLKFGAIRK MREDRWAVIA 960
KMDRKKKLKE AEKLFV 976 
Gene Ontology
 GO:0000801; C:central element; IEA:Compara.
 GO:0001673; C:male germ cell nucleus; IEA:Compara.
 GO:0000802; C:transverse filament; IEA:Compara.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007131; P:reciprocal meiotic recombination; TAS:ProtInc.
 GO:0032880; P:regulation of protein localization; IEA:Compara.
 GO:0007283; P:spermatogenesis; TAS:ProtInc.
 GO:0007130; P:synaptonemal complex assembly; ISS:HGNC. 
Interpro
 IPR008827; SCP-1. 
Pfam
 PF05483; SCP-1 
SMART
  
PROSITE
  
PRINTS