CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022523
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pogo transposable element with KRAB domain 
Protein Synonyms/Alias
  
Gene Name
 POGK 
Gene Synonyms/Alias
 KIAA1513; LST003; SLTP003 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
35DGPADMQKVRICSEGubiquitination[1]
222TNNCQAAKQFGVLEKubiquitination[1]
276YVRYMQAKGDPITREubiquitination[1]
301QEMNIPEKGFKASLGubiquitination[1]
304NIPEKGFKASLGWCRubiquitination[1]
338LPEDLTEKLVTYQRSubiquitination[2]
384TVDNQGEKPVLVKTPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 
Functional Description
  
Sequence Annotation
 DOMAIN 47 118 KRAB.
 DOMAIN 250 323 HTH CENPB-type.
 DOMAIN 353 567 DDE.  
Keyword
 Coiled coil; Complete proteome; Developmental protein; DNA-binding; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 609 AA 
Protein Sequence
MESTAYPLNL SLKEEEEEEE IQSRELEDGP ADMQKVRICS EGGWVPALFD EVAIYFSDEE 60
WEVLTEQQKA LYREVMRMNY ETVLSLEFPF PKPDMITRLE GEEESQNSDE WQLQGGTSAE 120
NEESDVKPPD WPNPMNATSQ FPQPQHFDSF GLRLPRDITE LPEWSEGYPF YMAMGFPGYD 180
LSADDIAGKF QFSRGMRRSY DAGFKLMVVE YAESTNNCQA AKQFGVLEKN VRDWRKVKPQ 240
LQNAHAMRRA FRGPKNGRFA LVDQRVAEYV RYMQAKGDPI TREAMQLKAL EIAQEMNIPE 300
KGFKASLGWC RRMMRRYDLS LRHKVPVPQH LPEDLTEKLV TYQRSVLALR RAHDYEVAQM 360
GNADETPICL EVPSRVTVDN QGEKPVLVKT PGREKLKITA MLGVLADGRK LPPYIILRGT 420
YIPPGKFPSG MEIRCHRYGW MTEDLMQDWL EVVWRRRTGA VPKQRGMLIL NGFRGHATDS 480
VKNSMESMNT DMVIIPGGLT SQLQVLDVVV YKPLNDSVRA QYSNWLLAGN LALSPTGNAK 540
KPPLGLFLEW VMVAWNSISS ESIVQGFKKC HISSNLEEED DVLWEIESEL PGGGEPPKDC 600
DTESMAESN 609 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR018586; Brinker_DNA-bd.
 IPR004875; DDE_SF_endonuclease_CENPB-like.
 IPR009057; Homeodomain-like.
 IPR006600; HTH_CenpB_DNA-bd_dom.
 IPR001909; Krueppel-associated_box. 
Pfam
 PF09607; BrkDBD
 PF03184; DDE_1
 PF03221; HTH_Tnp_Tc5
 PF01352; KRAB 
SMART
 SM00674; CENPB
 SM00349; KRAB 
PROSITE
 PS51253; HTH_CENPB
 PS50805; KRAB 
PRINTS