CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017528
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transmembrane protein 102 
Protein Synonyms/Alias
 Common beta-chain associated protein; CBAP 
Gene Name
 TMEM102 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
64GADLLRAKDFVFSLLubiquitination[1]
233LGSTAPLKTMSSDVTubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway. 
Sequence Annotation
 MOD_RES 209 209 Phosphoserine (By similarity).  
Keyword
 Apoptosis; Cell membrane; Complete proteome; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 508 AA 
Protein Sequence
MASAVWGSAP WWGPPPPAPA RPLTDIDFCS GAQLQELTQL IQELGVQESW SDGPKPGADL 60
LRAKDFVFSL LGLVHRRDPR FPPQAELLLL RGGIREGSLD LGHAPLGPYA RGPHYDAGFT 120
LLVPMFSLDG TELQLDLESC YAQVCLPEMV CGTPIREMWQ DCLGPPVPGA RDSIHRTESE 180
ESSKDWQSSV DQPHSYVTEH EAPVSLEKSP SDVSASESPQ HDVVDLGSTA PLKTMSSDVT 240
KAAVESPVPK PSEAREAWPT LCSAQVAAWF FATLAAVAES LIPVPGAPRL VHAARHAGFT 300
TVLLATPEPP RRLLLFDLIP VVSVAGWPEG ARSHSWAGPL ASESASFYLV PGGGTERPCA 360
SAWQLCFARQ ELALKARIPA PLLQAHAAAQ ALLRPLVAGT RAAAPYLLRT LLYWACERLP 420
ALYLARPENA GACCLGLLDE LGRVLEAGTL PHYFLNGRQL RTGDDSAALL GELARLRGDP 480
ARALRAAVEE AKVARKGGGL AGVGGGAH 508 
Gene Ontology
 GO:0009986; C:cell surface; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005622; C:intracellular; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:1901028; P:regulation of mitochondrial outer membrane permeabilization; IDA:UniProtKB.
 GO:0034097; P:response to cytokine stimulus; IDA:UniProtKB.
 GO:0007165; P:signal transduction; IDA:UniProtKB. 
Interpro
 IPR020950; Mab-21-rel.
 IPR024810; Mab-21_dom.
 IPR024806; TMEM102. 
Pfam
 PF03281; Mab-21 
SMART
  
PROSITE
  
PRINTS