CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028599
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Glutathione S-transferase Mu 1 
Protein Synonyms/Alias
  
Gene Name
 Gstm1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
31TDSSYDEKRYTMGDAacetylation[1, 2, 3]
31TDSSYDEKRYTMGDAubiquitination[4]
50RSQWLNEKFKLGLDFacetylation[5]
50RSQWLNEKFKLGLDFsuccinylation[5]
50RSQWLNEKFKLGLDFubiquitination[4]
52QWLNEKFKLGLDFPNacetylation[1, 6]
52QWLNEKFKLGLDFPNubiquitination[4]
69YLIDGSHKITQSNAIubiquitination[4]
83ILRYLARKHHLDGETubiquitination[4]
150SLPQEKQKPEFLKTIacetylation[3]
150SLPQEKQKPEFLKTIubiquitination[4]
155KQKPEFLKTIPEKMKacetylation[3, 7]
155KQKPEFLKTIPEKMKubiquitination[4]
162KTIPEKMKLYSEFLGacetylation[1, 5, 6]
162KTIPEKMKLYSEFLGsuccinylation[5]
162KTIPEKMKLYSEFLGubiquitination[4]
170LYSEFLGKRPWFAGDacetylation[1, 3, 5]
170LYSEFLGKRPWFAGDsuccinylation[5]
170LYSEFLGKRPWFAGDubiquitination[4]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [6] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [7] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 201 AA 
Protein Sequence
MPMILGYWNV RGLTHPIRML LEYTDSSYDE KRYTMGDAPD FDRSQWLNEK FKLGLDFPNL 60
PYLIDGSHKI TQSNAILRYL ARKHHLDGET EEERIRADIV ENQVMDTRMQ LIMLCYNPDF 120
VAVPLPNPLL GSLSLKVVTA SCSLPQEKQK PEFLKTIPEK MKLYSEFLGK RPWFAGDKVT 180
YVDFLAYDIL DQYRMFEPKC L 201 
Gene Ontology
 GO:0004364; F:glutathione transferase activity; IEA:InterPro.
 GO:0046982; F:protein heterodimerization activity; IDA:MGI.
 GO:0042803; F:protein homodimerization activity; IDA:MGI.
 GO:0035690; P:cellular response to drug; IDA:MGI. 
Interpro
 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR004046; GST_C.
 IPR003081; GST_mu.
 IPR012336; Thioredoxin-like_fold. 
Pfam
 PF00043; GST_C
 PF02798; GST_N 
SMART
  
PROSITE
 PS50405; GST_CTER
 PS50404; GST_NTER 
PRINTS
 PR01267; GSTRNSFRASEM.