CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013081
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial ribonuclease P protein 1 
Protein Synonyms/Alias
 Mitochondrial RNase P protein 1; RNA (guanine-9-)-methyltransferase domain-containing protein 1; tRNA methyltransferase 10 homolog C 
Gene Name
 Trmt10c 
Gene Synonyms/Alias
 Mrpp1; Rg9mtd1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
369GNWEEALKFVPRRKHacetylation[1]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends (By similarity). 
Sequence Annotation
 DOMAIN 186 378 SAM-dependent MTase TRM10-type.  
Keyword
 Coiled coil; Complete proteome; Methyltransferase; Mitochondrion; Mitochondrion nucleoid; Reference proteome; S-adenosyl-L-methionine; Transferase; Transit peptide; tRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 414 AA 
Protein Sequence
MNVTVRFLRP FARCLVPYTF HRKRSHLYSG VLQRYMSSKA PSLSCHNKDS ASPPEQLELD 60
GWKATMKSSI QEDGVSEVSD KDEDSLASTR ELIEMWRLLG KEVPEHITEE DLKTLMECAS 120
KSAKKKYLRY LYGKEKAKKA KQVKKEMKAE AREEAKRARL LETTAEEQQQ DFMFLRLWDR 180
QINIALGWKG VQAMQFGQPL VFDMAYDNYM KPSELQNTVS QLLESEGWNR RNVDPFHIYF 240
CNLKIDSAYH RELVKRYREK WDKLLLTATE KSPVDLFPKD SIIYLTADSP NVMTTFKHDK 300
IYIIGSFVDK NTQTGTSLAK AKRLNIATEC LPLDKYLQWE IGNKNLTLDQ MIRILLCLKN 360
TGNWEEALKF VPRRKHTGYL EVSEQSQELV RKLKKTKTLN SFRKGSLNVR TWKR 414 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
 GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR025812; Mt_RNase_P_1.
 IPR016009; tRNA_m1G_MeTrfase.
 IPR007356; tRNA_m1G_MeTrfase_euk. 
Pfam
 PF01746; tRNA_m1G_MT 
SMART
  
PROSITE
 PS51675; SAM_MT_TRM10 
PRINTS