CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039197
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Mef2c 
Protein Synonyms/Alias
  
Gene Name
 Mef2c 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
463ERESPSVKRMRLSEGacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 473 AA 
Protein Sequence
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS TNKLFQYAST 60
DMDKVLLKYT EYNEPHESRT NSDIVETLRK KGLNGCDSPD PDADDSVGHS PESEDKYRKI 120
NEDIDLMISR QRLCAVPPPN FEMPVTIPVS SHNSLVYSNP VSSLGNPNLL PLAHPSLQRN 180
SMSPGVTHRP PSAGNTGGLM GGDLTSGAGT SAGNGYGNPR NSPGLLVSPG NLNKNIQAKS 240
PPPMNLGMNN RKPDLRVLIP PGSKNTMPSV VMHNSVLNNQ RINNSQSAQS LATPVVSVAT 300
PTLPGQGMGG YPSAISTTYG TEYSLSSADL SSLSGFNTAS ALHLGSVTGW QQQHLHNMPP 360
SALSQLGACT STHLSQSSNL SLPSTQSLNI KSEPVSPPRD RTTTPSRYPQ HTRHEAGRSP 420
VDSLSSCSSS YDGSDREDHR NEFHSPIGLT RPSPDERESP SVKRMRLSEG WAT 473 
Gene Ontology
 GO:0016607; C:nuclear speck; ISS:UniProtKB.
 GO:0043234; C:protein complex; ISS:UniProtKB.
 GO:0030017; C:sarcomere; IDA:UniProtKB.
 GO:0035198; F:miRNA binding; ISS:UniProtKB.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; ISS:UniProtKB.
 GO:0000983; F:RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; ISS:UniProtKB.
 GO:0001782; P:B cell homeostasis; ISS:UniProtKB.
 GO:0042100; P:B cell proliferation; ISS:UniProtKB.
 GO:0050853; P:B cell receptor signaling pathway; ISS:UniProtKB.
 GO:0071277; P:cellular response to calcium ion; ISS:UniProtKB.
 GO:0035690; P:cellular response to drug; ISS:UniProtKB.
 GO:0071498; P:cellular response to fluid shear stress; ISS:UniProtKB.
 GO:0071333; P:cellular response to glucose stimulus; IEP:RGD.
 GO:0071222; P:cellular response to lipopolysaccharide; ISS:UniProtKB.
 GO:0071374; P:cellular response to parathyroid hormone stimulus; ISS:UniProtKB.
 GO:0071300; P:cellular response to retinoic acid; IDA:RGD.
 GO:0071560; P:cellular response to transforming growth factor beta stimulus; ISS:UniProtKB.
 GO:0035984; P:cellular response to trichostatin A; ISS:UniProtKB.
 GO:0021542; P:dentate gyrus development; IEP:RGD.
 GO:2001013; P:epithelial cell proliferation involved in renal tubule morphogenesis; ISS:UniProtKB.
 GO:0002467; P:germinal center formation; ISS:UniProtKB.
 GO:0072102; P:glomerulus morphogenesis; ISS:UniProtKB.
 GO:0001947; P:heart looping; ISS:UniProtKB.
 GO:0006959; P:humoral immune response; ISS:UniProtKB.
 GO:0007611; P:learning or memory; ISS:UniProtKB.
 GO:0000165; P:MAPK cascade; ISS:UniProtKB.
 GO:0030318; P:melanocyte differentiation; ISS:UniProtKB.
 GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
 GO:0030279; P:negative regulation of ossification; ISS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0072160; P:nephron tubule epithelial cell differentiation; ISS:UniProtKB.
 GO:0014033; P:neural crest cell differentiation; ISS:UniProtKB.
 GO:0048666; P:neuron development; ISS:UniProtKB.
 GO:0030220; P:platelet formation; ISS:UniProtKB.
 GO:0010694; P:positive regulation of alkaline phosphatase activity; ISS:UniProtKB.
 GO:0030890; P:positive regulation of B cell proliferation; ISS:UniProtKB.
 GO:2000987; P:positive regulation of behavioral fear response; ISS:UniProtKB.
 GO:0030501; P:positive regulation of bone mineralization; ISS:UniProtKB.
 GO:2000727; P:positive regulation of cardiac muscle cell differentiation; ISS:UniProtKB.
 GO:0060045; P:positive regulation of cardiac muscle cell proliferation; ISS:UniProtKB.
 GO:0010613; P:positive regulation of cardiac muscle hypertrophy; IMP:UniProtKB.
 GO:2000111; P:positive regulation of macrophage apoptotic process; ISS:UniProtKB.
 GO:0045663; P:positive regulation of myoblast differentiation; ISS:UniProtKB.
 GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB.
 GO:0045669; P:positive regulation of osteoblast differentiation; ISS:UniProtKB.
 GO:2001016; P:positive regulation of skeletal muscle cell differentiation; ISS:UniProtKB.
 GO:0048643; P:positive regulation of skeletal muscle tissue development; ISS:UniProtKB.
 GO:0003138; P:primary heart field specification; ISS:UniProtKB.
 GO:0002634; P:regulation of germinal center formation; ISS:UniProtKB.
 GO:0045652; P:regulation of megakaryocyte differentiation; ISS:UniProtKB.
 GO:0060025; P:regulation of synaptic activity; ISS:UniProtKB.
 GO:0033197; P:response to vitamin E; IEP:RGD.
 GO:0003139; P:secondary heart field specification; ISS:UniProtKB.
 GO:0003185; P:sinoatrial valve morphogenesis; ISS:UniProtKB.
 GO:0055012; P:ventricular cardiac muscle cell differentiation; ISS:UniProtKB. 
Interpro
 IPR022102; HJURP_C.
 IPR002100; TF_MADSbox. 
Pfam
 PF12347; HJURP_C
 PF00319; SRF-TF 
SMART
 SM00432; MADS 
PROSITE
 PS00350; MADS_BOX_1
 PS50066; MADS_BOX_2 
PRINTS
 PR00404; MADSDOMAIN.