CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028886
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ribosomal protein S6 kinase alpha-6 
Protein Synonyms/Alias
  
Gene Name
 Rps6ka6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
586ICDFGFAKQLRGENGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 760 AA 
Protein Sequence
MLVLGPGSFF SRAPEAAMLP FAPVEDPWDQ EDMEVFGSTS SSEVNDLKMV DEPMEEGEPV 60
SCRREELVKE IPITQHVKEG YEKADPAQFD LLKVLGQGSF GKVFLVRKKT GPDAGQLYAM 120
KVLRKASLKV RDRVRTKMER DILVEVNHPF IVKLHYAFQT EGKLYLILDF LRGGDVFTRL 180
SKEVLFTEED VKFYLAELAL ALDHLHRLGI VYRDLKPENI LLDEIGHIKL TDFGLSKESV 240
DQEKKAYSFC GTVEYMAPEV VNRRGHSQSA DWWSYGVLMF EMLTGTLPFQ GKDRNETMNM 300
ILKAKLGMPQ FLSAEAQSLL RMLFKRNPAN RLGSEGVEEV KRHAFFASID WNKLYKREVQ 360
PPFRPASGKP DDTFCFDPEF TAKTPKDSPG LPASANAHQL FKGFSFVATS IAEEYKITPV 420
TSSNVLPIVQ INGNAAQFSE AYELKEDIGI GSYSVCKRCI HSASNVEFAV KIIDKNKRDP 480
SEEIEILMRY GQHPNIISLK EVFDDGKYVY LVTDLMKGGE LLDRILKKKC FSEQEASNVL 540
YVITKTVECL HSQGVVHRDL KPSNILYMDE SAHPDSIKIC DFGFAKQLRG ENGLLLTPCY 600
TANFVAPEVL TQQGYDAACD IWSLGVLLYT MLAGYTPFSN GPNDTPEEIL LRIGNGRFSL 660
SGGIWDNISR GAKDLLSHML HMDPHQRYTA EQVLKHPWIT QREQLPRHQP NSDEPPQEAV 720
AAPYSVLARN PNRHHPILEP VTASRLAQRR NMKKRTSTGL 760 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro. 
Interpro
 IPR000961; AGC-kinase_C.
 IPR011009; Kinase-like_dom.
 IPR017892; Pkinase_C.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR016239; Ribosomal_S6_kinase_II.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase
 PF00433; Pkinase_C 
SMART
 SM00133; S_TK_X
 SM00220; S_TKc 
PROSITE
 PS51285; AGC_KINASE_CTER
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS