CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015499
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 574 
Protein Synonyms/Alias
  
Gene Name
 ZNF574 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
494KTFVNLTKFLYHRRTubiquitination[1]
566LCSREFGKALQLTRHubiquitination[1]
619FPCPDCSKPFNSPANubiquitination[1]
647YRCGDCGKAFTQSSTubiquitination[1, 2]
697HTGEYPYKCRECPRSubiquitination[1]
789GPGEVLAKEPPAPRAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 ZN_FING 16 38 C2H2-type 1.
 ZN_FING 76 98 C2H2-type 2.
 ZN_FING 126 148 C2H2-type 3.
 ZN_FING 214 236 C2H2-type 4.
 ZN_FING 309 331 C2H2-type 5.
 ZN_FING 336 358 C2H2-type 6.
 ZN_FING 364 386 C2H2-type 7.
 ZN_FING 392 413 C2H2-type 8.
 ZN_FING 466 489 C2H2-type 9.
 ZN_FING 495 517 C2H2-type 10; degenerate.
 ZN_FING 523 545 C2H2-type 11.
 ZN_FING 551 573 C2H2-type 12.
 ZN_FING 579 601 C2H2-type 13.
 ZN_FING 607 630 C2H2-type 14.
 ZN_FING 636 659 C2H2-type 15; degenerate.
 ZN_FING 667 689 C2H2-type 16.
 ZN_FING 738 760 C2H2-type 17.
 ZN_FING 766 788 C2H2-type 18.
 ZN_FING 794 816 C2H2-type 19.
 ZN_FING 822 844 C2H2-type 20.
 MOD_RES 164 164 Phosphoserine.
 MOD_RES 298 298 Phosphoserine.
 MOD_RES 717 717 Phosphoserine.
 MOD_RES 724 724 Phosphothreonine.
 MOD_RES 728 728 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 896 AA 
Protein Sequence
MPRATWANSK ERSWAESERG PRDTGNGGSK AERHIQEIET GRGGDRAKAH RRQRMRLRGT 60
ERASLGPGRR LGDSRGTDMP GARAQGLAAA TEESEETVLY IEHRYVCSEC NQLYGSLEEV 120
LMHQNSHVPQ QHFELVGVAD PGVTVATDTA SGTGLYQTLV QESQYQCLEC GQLLMSPSQL 180
LEHQELHLKM MAPQEAVPAE PSPKAPPLSS STIHYECVDC KALFASQELW LNHRQTHLRA 240
TPTKAPAPVV LGSPVVLGPP VGQARVAVEH SYRKAEEGGE GATVPSAAAT TTEVVTEVEL 300
LLYKCSECSQ LFQLPADFLE HQATHFPAPV PESQEPALQQ EVQASSPAEV PVSQPDPLPA 360
SDHSYELRNG EAIGRDRRGR RARRNNSGEA GGAATQELFC SACDQLFLSP HQLQQHLRSH 420
REGVFKCPLC SRVFPSPSSL DQHLGDHSSE SHFLCVDCGL AFGTEALLLA HRRAHTPNPL 480
HSCPCGKTFV NLTKFLYHRR THGVGGVPLP TTPVPPEEPV IGFPEPAPAE TGEPEAPEPP 540
VSEETSAGPA APGTYRCLLC SREFGKALQL TRHQRFVHRL ERRHKCSICG KMFKKKSHVR 600
NHLRTHTGER PFPCPDCSKP FNSPANLARH RLTHTGERPY RCGDCGKAFT QSSTLRQHRL 660
VHAQHFPYRC QECGVRFHRP YRLLMHRYHH TGEYPYKCRE CPRSFLLRRL LEVHQLVVHA 720
GRQPHRCPSC GAAFPSSLRL REHRCAAAAA QAPRRFECGT CGKKVGSAAR LQAHEAAHAA 780
AGPGEVLAKE PPAPRAPRAT RAPVASPAAL GSTATASPAA PARRRGLECS ECKKLFSTET 840
SLQVHRRIHT GERPYPCPDC GKAFRQSTHL KDHRRLHTGE RPFACEVCGK AFAISMRLAE 900
HRRIHTGERP YSCPDCGKSY RSFSNLWKHR KTHQQQHQAA VRQQLAEAEA AVGLAVMETA 960
VEALPLVEAI EIYPLAEAEG VQISG 985 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS