CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016342
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rab11 family-interacting protein 4 
Protein Synonyms/Alias
 FIP4-Rab11; Rab11-FIP4; Arfophilin-2 
Gene Name
 RAB11FIP4 
Gene Synonyms/Alias
 ARFO2; KIAA1821 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
505ELIEDLRKELEHLQMubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. 
Sequence Annotation
 DOMAIN 49 84 EF-hand.
 DOMAIN 574 636 FIP-RBD.
 REGION 82 637 Necessary for interaction with RAB11A,  
Keyword
 Alternative splicing; Calcium; Coiled coil; Complete proteome; Cytoplasmic vesicle; Endosome; Host-virus interaction; Membrane; Metal-binding; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 637 AA 
Protein Sequence
MAGGAGWSGA PAALLRSVRR LREVFEVCGR DPDGFLRVER VAALGLRFGQ GEEVEKLVKY 60
LDPNDLGRIN FKDFCRGVFA MKGCEELLKD VLSVESAGTL PCAPEIPDCV EQGSEVTGPT 120
FADGELIPRE PGFFPEDEEE AMTLAPPEGP QELYTDSPME STQSLEGSVG SPAEKDGGLG 180
GLFLPEDKSL VHTPSMTTSD LSTHSTTSLI SNEEQFEDYG EGDDVDCAPS SPCPDDETRT 240
NVYSDLGSSV SSSAGQTPRK MRHVYNSELL DVYCSQCCKK INLLNDLEAR LKNLKANSPN 300
RKISSTAFGR QLMHSSNFSS SNGSTEDLFR DSIDSCDNDI TEKVSFLEKK VTELENDSLT 360
NGDLKSKLKQ ENTQLVHRVH ELEEMVKDQE TTAEQALEEE ARRHREAYGK LEREKATEVE 420
LLNARVQQLE EENTELRTTV TRLKSQTEKL DEERQRMSDR LEDTSLRLKD EMDLYKRMMD 480
KLRQNRLEFQ KEREATQELI EDLRKELEHL QMYKLDCERP GRGRSASSGL GEFNARAREV 540
ELEHEVKRLK QENYKLRDQN DDLNGQILSL SLYEAKNLFA AQTKAQSLAA EIDTASRDEL 600
MEALKEQEEI NFRLRQYMDK IILAILDHNP SILEIKH 637 
Gene Ontology
 GO:0032154; C:cleavage furrow; IDA:UniProtKB.
 GO:0030139; C:endocytic vesicle; IDA:UniProtKB.
 GO:0030496; C:midbody; IDA:UniProtKB.
 GO:0055038; C:recycling endosome membrane; IDA:UniProtKB.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0000910; P:cytokinesis; IMP:UniProtKB.
 GO:0006810; P:transport; IEA:UniProtKB-KW.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom.
 IPR019018; Rab-bd_FIP-RBD. 
Pfam
 PF09457; RBD-FIP 
SMART
  
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS51511; FIP_RBD 
PRINTS