UniProt Accession

 TSC1_RAT; Q9Z136 

Genbank Protein ID

 AB011821 

Genbank Nucleotide ID

 BAA75254.1 

Protein Name

 Hamartin 

Protein Synonyms/Alias

 Tuberous sclerosis 1 protein homolog 

Gene Name

 Tsc1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
886	MMKTAYRKELEKNRS	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). 

Sequence Annotation

 MOD_RES 394 394 Phosphoserine (By similarity).
 MOD_RES 505 505 Phosphoserine (By similarity).
 MOD_RES 511 511 Phosphoserine (By similarity).
 MOD_RES 598 598 Phosphoserine (By similarity).  

Keyword

 Coiled coil; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Reference proteome; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1163 AA 

Protein Sequence

Gene Ontology

 GO:0005884; C:actin filament; IEA:Compara.
 GO:0005938; C:cell cortex; IEA:Compara.
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0030426; C:growth cone; IDA:RGD.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0033596; C:TSC1-TSC2 complex; IEA:Compara.
 GO:0030695; F:GTPase regulator activity; IMP:RGD.
 GO:0032862; P:activation of Rho GTPase activity; IEA:Compara.
 GO:0055007; P:cardiac muscle cell differentiation; IEA:Compara.
 GO:0030030; P:cell projection organization; IEA:Compara.
 GO:0007160; P:cell-matrix adhesion; IEA:Compara.
 GO:0021987; P:cerebral cortex development; IEA:Compara.
 GO:0021766; P:hippocampus development; IEA:Compara.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0042552; P:myelination; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0045792; P:negative regulation of cell size; IEA:Compara.
 GO:0032007; P:negative regulation of TOR signaling cascade; IEA:Compara.
 GO:0017148; P:negative regulation of translation; IEA:Compara.
 GO:0001843; P:neural tube closure; IEA:Compara.
 GO:0051894; P:positive regulation of focal adhesion assembly; IEA:Compara.
 GO:0006813; P:potassium ion transport; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IDA:RGD.
 GO:0050821; P:protein stabilization; IEA:Compara.
 GO:0051893; P:regulation of focal adhesion assembly; IMP:RGD.
 GO:0043666; P:regulation of phosphoprotein phosphatase activity; IEA:Compara.
 GO:0045859; P:regulation of protein kinase activity; IEA:Compara.
 GO:0051492; P:regulation of stress fiber assembly; IMP:RGD.
 GO:0032868; P:response to insulin stimulus; IEA:Compara.
 GO:0006407; P:rRNA export from nucleus; IEA:Compara.
 GO:0050808; P:synapse organization; IEA:Compara. 

Interpro

 IPR007483; Hamartin. 

Pfam

 PF04388; Hamartin 

SMART

  

PROSITE

  

PRINTS