UniProt Accession

 H2AW_MOUSE; Q8CCK0; A0JP36; Q3TNT4; Q925I6 

Genbank Protein ID

 AF336305; AK032636; AK165020; BC045140; BC046794; BC107279; BC107280; BC127144 

Genbank Nucleotide ID

 AAK52472.1; BAC27963.1; BAE38003.1; AAH45140.1; AAH46794.1; AAI07280.1; AAI07281.1; AAI27145.1 

Protein Name

 Core histone macro-H2A.2 

Protein Synonyms/Alias

 Histone macroH2A2; mH2A2 

Gene Name

 H2afy2 

Gene Synonyms/Alias

 H2afy3 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
116	IHPELLAKKRGTKGK	ubiquitination	[1]
134	ILSPPPEKRGRKAAS	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation. 

Sequence Annotation

 DOMAIN 2 117 Histone H2A.
 DOMAIN 184 370 Macro.  

Keyword

 Chromatin regulator; Chromosome; Complete proteome; DNA-binding; Nucleosome core; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 372 AA 

Protein Sequence

Gene Ontology

 GO:0001740; C:Barr body; ISA:MGI.
 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0007549; P:dosage compensation; ISA:MGI.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR002589; A1pp.
 IPR021171; Core_histone_macro-H2A.
 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR002119; Histone_H2A. 

Pfam

 PF00125; Histone
 PF01661; Macro 

SMART

 SM00414; H2A 

PROSITE

 PS51154; MACRO 

PRINTS

 PR00620; HISTONEH2A.