| Tag | Content |
|---|
| CPLM ID | CPLM-024731 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | RILP-like protein 1 |
Protein Synonyms/Alias | GAPDH's competitor of SIAH1 protein enhances life; GOSPEL; Rab-interacting lysosomal-like protein 1 |
Gene Name | Rilpl1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 203 | QQQTRLMKINHDLRH | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH. Does not regulate lysosomal morphology and distribution. |
Sequence Annotation | DOMAIN 290 324 RILP-like.
MOD_RES 47 47 S-nitrosocysteine.
MOD_RES 328 328 Phosphoserine (By similarity). |
Keyword | Coiled coil; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; S-nitrosylation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 406 AA |
Protein Sequence | MEEPLGSPPA ALSALEKNVA ELTVMDVYDI ASLVGHEFER VIDQHGCEAI ARLMPKVVRV 60
LEILEVLVSR HHVAPELDEL RLELDRLRVE RMDRIEKERK HQKELELVED VWRGEAQDLL 120
SQIAQLQEEN KQLMTNLNHK DVGFSEEELQ KHEGMSERER QVMKRLKEVV DKQRDEIRAK 180
DRELVLKNED VEALQQQQTR LMKINHDLRH RVTVVEAQGK ALIEQKVELE ADLQTKEQEM 240
GSLRAELGKL RERLQGEHSQ NGEEEEAEIP PQPDGEESIS DAEKAALDLK DPNRPRFTLQ 300
ELRDVLHERN ELKSKVFLLQ EELAYYKSEE IEEENRIPQP PPITHPRTSP QPESGIKRLF 360
SFFSRDKRRL ANTQRPTHIH ESFGQWAITH RDDGYTEQGQ EALQHL 406 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |