CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040577
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Signal recognition particle subunit SRP72 
Protein Synonyms/Alias
  
Gene Name
 Srp72 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
112TQQTDKLKELYGQVLubiquitination[1]
297NAEGVEFKLSKRQLQubiquitination[1]
383KLTMAQLKISQGNISubiquitination[1]
391ISQGNISKACLILRSubiquitination[1]
479QLWKQNSKDIHTLAQubiquitination[1]
498YSLVDPEKAKALSKHubiquitination[1]
569LPKNYDPKVTPDPERubiquitination[1]
600KKKDQIGKGTQGATAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasm; Reference proteome; Ribonucleoprotein; Signal recognition particle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 671 AA 
Protein Sequence
MASGGSGGVS VPALWSEVNR YGQNSDFTRA LKTVNKILQI NKDDVTALHC KVVCLIQNGS 60
FKEALNVINT HTKVLANNSL SFEKAYCEYR LNRIENALKT IESATQQTDK LKELYGQVLY 120
RLERYDECLA VYRDLVRNSQ DDYDEERKTN LSAVVAAQSN WEKVVPENLG LQEGTHELCY 180
NAACALIGQG QLTQAMKILQ KAEDLCRRSF SEDSDGAEED PQAELAIIHG QMAYIMQLQG 240
RTEEALQLYN QIIKLKPTDV ALLAVIANNI ITINKDQNVF DSKKKVKLTN AEGVEFKLSK 300
RQLQAIEFNK ALLAMYTNQA EQCRKIAASL QSQSPEYLLP VLIQAAQLCR EKQHTKAIEL 360
LQEFSDQHPE NAAEIKLTMA QLKISQGNIS KACLILRSIE ELRHKPGMVS ALVTMYSHEE 420
DIDSAIEVFT QAIQWYQSHQ PKSPAHLSLI REAANFKLKY GRKKEAVSDL EQLWKQNSKD 480
IHTLAQLISA YSLVDPEKAK ALSKHLPSSD SMSLKVDVEA LENSPGATYI RKKGGKVTGD 540
NQPKEQGQGD LKKKKKKKKG KLPKNYDPKV TPDPERWLPM RERSYYRGRK KGKKKDQIGK 600
GTQGATAGAS SELDASKAVS SPPTSPRPGS AATISSSASN IVPPRHQKPA GAPATKKKQQ 660
QKKKKGGKSG W 671 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; ISA:MGI.
 GO:0008312; F:7S RNA binding; IEA:InterPro.
 GO:0005047; F:signal recognition particle binding; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; ISA:MGI. 
Interpro
 IPR013699; Signal_recog_part_SRP72_RNA-bd.
 IPR026270; SRP72.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF08492; SRP72
 PF13174; TPR_6 
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS