| Tag | Content |
|---|
| CPLM ID | CPLM-018690 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Metalloreductase STEAP4 |
Protein Synonyms/Alias | Dudulin-4; Six-transmembrane epithelial antigen of prostate 4; Tumor necrosis factor-alpha-induced adipose-related protein |
Gene Name | Steap4 |
Gene Synonyms/Alias | Tiarp |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 3 | *****MEKAHADEFP | ubiquitination | [1] | | 18 | LTTDSSEKQGVVCIF | ubiquitination | [1] | | 97 | TELVDYLKGKVLVDV | ubiquitination | [1] | | 99 | LVDYLKGKVLVDVSN | ubiquitination | [1] | | 109 | VDVSNNRKINQYPES | ubiquitination | [1] | | 161 | FVCGNDSKAKQRVMD | ubiquitination | [1] | | 458 | QGWERNSKYTQSALN | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Inhibits anchorage-independent cell proliferation (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses. |
Sequence Annotation | DOMAIN 247 395 Ferric oxidoreductase.
METAL 304 304 Iron (heme axial ligand) (By similarity).
METAL 397 397 Iron (heme axial ligand) (By similarity). |
Keyword | Cell membrane; Complete proteome; Copper; FAD; Flavoprotein; Golgi apparatus; Ion transport; Iron; Iron transport; Membrane; Metal-binding; NAD; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 470 AA |
Protein Sequence | MEKAHADEFP LTTDSSEKQG VVCIFGTGDF GKSLGLKMLQ CGYSIVFGSR NPQVSSLLPR 60
GAEVLSYSEA ASKSDIIILA MHREHYDSLT ELVDYLKGKV LVDVSNNRKI NQYPESNAEY 120
LAQLEPGAHV VKAFNTISAW ALQSGTLDAS RQVFVCGNDS KAKQRVMDIA RTLGLTPLDQ 180
GSLMAASEIE NYPLQLFPMW RFPFYLSSVL CVFFFVYCAI REVIYPYVNG KTDATYRLAI 240
SIPNRVFPIT ALILLALVYL PGILAAILQL YRGTKYRRFP NWLDHWMLCR KQLGLVALGF 300
AFLHVIYTLV IPIRYYVRWR LRNATITQAL TNKDSPFITS YAWINDSYLA LGILGFFLFL 360
LLGITSLPSV SNMVNWREFR FVQSKLGYLT LVLCTAHTLV YGGKRFLSPS ILRWSLPSAY 420
ILALVIPCAV LVLKCILIMP CIDKTLTRIR QGWERNSKYT QSALNGKSDI 470 |
Gene Ontology | GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0005887; C:integral to plasma membrane; TAS:UniProtKB. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. GO:0045444; P:fat cell differentiation; IEP:UniProtKB. GO:0006811; P:ion transport; IEA:UniProtKB-KW. GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |