UniProt Accession

 AP1AR_HUMAN; Q63HQ0; Q96GG6; Q9H0V0; Q9P1L4 

Genbank Protein ID

 AL136628; BX647702; AC109347; BC009485; AF116612 

Genbank Nucleotide ID

 CAB66563.1; CAH56145.1; AAY40962.1; AAH09485.1; AAF71037.1 

Protein Name

 AP-1 complex-associated regulatory protein 

Protein Synonyms/Alias

 2c18; Adapter-related protein complex 1-associated regulatory protein; Gamma-1-adaptin brefeldin A resistance protein; GBAR; Gamma-BAR 

Gene Name

 AP1AR 

Gene Synonyms/Alias

 C4orf16; PRO0971 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
30	VGGGGGSKYFRTCSR	ubiquitination	[1, 2]
93	DLDKKIQKELALQEE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Necessary for AP-1 dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/Gamma1-adaptin, one of the subunits of the AP-1 adapter complex. The direct interaction with AP1G1/Gamma1- adaptin attenuates the release of the AP-1 complex from membranes. 

Sequence Annotation

 REGION 78 138 Interaction with AP1G1.
 MOD_RES 228 228 Phosphothreonine.
 CARBOHYD 247 247 N-linked (GlcNAc...).  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Endosome; Glycoprotein; Golgi apparatus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 302 AA 

Protein Sequence

Gene Ontology

 GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0030133; C:transport vesicle; IDA:LIFEdb.
 GO:0034613; P:cellular protein localization; IEA:Compara.
 GO:2000146; P:negative regulation of cell motility; IEA:Compara.
 GO:1900025; P:negative regulation of substrate adhesion-dependent cell spreading; IMP:MGI.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0034315; P:regulation of Arp2/3 complex-mediated actin nucleation; IEA:Compara. 

Interpro

  

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