| Tag | Content |
|---|
| CPLM ID | CPLM-012578 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription initiation factor TFIID subunit 5 |
Protein Synonyms/Alias | Transcription initiation factor TFIID 100 kDa subunit; TAF(II)100; TAFII-100; TAFII100 |
Gene Name | TAF5 |
Gene Synonyms/Alias | TAF2D |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 14 | EQTEVAVKLEPEGPP | sumoylation | [1] | | 508 | PKKLRSVKQASDLSL | ubiquitination | [2] |
|
Reference | [1] SUMO-1 modification of human transcription factor (TF) IID complex subunits: inhibition of TFIID promoter-binding activity through SUMO-1 modification of hsTAF5. Boyer-Guittaut M, Birsoy K, Potel C, Elliott G, Jaffray E, Desterro JM, Hay RT, Oelgeschläger T. J Biol Chem. 2005 Mar 18;280(11):9937-45. [ PMID: 15637059] [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also have been observed. |
Sequence Annotation | DOMAIN 92 124 LisH.
REPEAT 468 507 WD 1.
REPEAT 541 580 WD 2.
REPEAT 583 624 WD 3.
REPEAT 625 666 WD 4.
REPEAT 667 706 WD 5.
REPEAT 709 748 WD 6. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Host-virus interaction; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 800 AA |
Protein Sequence | MAALAEEQTE VAVKLEPEGP PTLLPPQAGD GAGEGSGGTT NNGPNGGGGN VAASSSTGGD 60
GGTPKPTVAV SAAAPAGAAP VPAAAPDAGA PHDRQTLLAV LQFLRQSKLR EAEEALRREA 120
GLLEEAVAGS GAPGEVDSAG AEVTSALLSR VTASAPGPAA PDPPGTGASG ATVVSGSASG 180
PAAPGKVGSV AVEDQPDVSA VLSAYNQQGD PTMYEEYYSG LKHFIECSLD CHRAELSQLF 240
YPLFVHMYLE LVYNQHENEA KSFFEKFHGD QECYYQDDLR VLSSLTKKEH MKGNETMLDF 300
RTSKFVLRIS RDSYQLLKRH LQEKQNNQIW NIVQEHLYID IFDGMPRSKQ QIDAMVGSLA 360
GEAKREANKS KVFFGLLKEP EIEVPLDDED EEGENEEGKP KKKKPKKDSI GSKSKKQDPN 420
APPQNRIPLP ELKDSDKLDK IMNMKETTKR VRLGPDCLPS ICFYTFLNAY QGLTAVDVTD 480
DSSLIAGGFA DSTVRVWSVT PKKLRSVKQA SDLSLIDKES DDVLERIMDE KTASELKILY 540
GHSGPVYGAS FSPDRNYLLS SSEDGTVRLW SLQTFTCLVG YKGHNYPVWD TQFSPYGYYF 600
VSGGHDRVAR LWATDHYQPL RIFAGHLADV NCTRFHPNSN YVATGSADRT VRLWDVLNGN 660
CVRIFTGHKG PIHSLTFSPN GRFLATGATD GRVLLWDIGH GLMVGELKGH TDTVCSLRFS 720
RDGEILASGS MDNTVRLWDA IKAFEDLETD DFTTATGHIN LPENSQELLL GTYMTKSTPV 780
VHLHFTRRNL VLAAGAYSPQ 800 |
Gene Ontology | GO:0015629; C:actin cytoskeleton; IDA:HPA. GO:0005669; C:transcription factor TFIID complex; IDA:UniProtKB. GO:0033276; C:transcription factor TFTC complex; IDA:UniProtKB. GO:0046983; F:protein dimerization activity; IDA:UniProtKB. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IMP:UniProtKB. GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB. GO:0016573; P:histone acetylation; IDA:GOC. GO:0006368; P:transcription elongation from RNA polymerase II promoter; TAS:Reactome. GO:0006367; P:transcription initiation from RNA polymerase II promoter; IDA:UniProtKB. GO:0022415; P:viral reproductive process; TAS:Reactome. GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. |
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