CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017813
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Carboxymethylenebutenolidase homolog 
Protein Synonyms/Alias
  
Gene Name
 Cmbl 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
105LKSRNARKVNREVDAubiquitination[1]
195STLTQKLKEHCIVNYacetylation[2]
195STLTQKLKEHCIVNYubiquitination[1]
227EDCSPADKPYIEEARacetylation[2, 3]
243NLIEWLNKYV*****acetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
 Cysteine hydrolase (By similarity). 
Sequence Annotation
 ACT_SITE 132 132 By similarity.
 ACT_SITE 179 179 By similarity.
 ACT_SITE 212 212 By similarity.
 MOD_RES 2 2 N-acetylalanine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 245 AA 
Protein Sequence
MANEANPCPC DIGHKLEYGG MGHEVQVEHI KAYVTRSPVD AGKAVIVVQD IFGWQLPNTR 60
YMADMIARNG YTTIVPDFFV GQEPWDPAGD WSTFPAWLKS RNARKVNREV DAVLRYLRQQ 120
CHAQKIGIVG FCWGGVVVHQ VMTAYPDIRA GVSVYGIIRD SEDVYNLKNP TLFIFAENDT 180
VIPLEQVSTL TQKLKEHCIV NYQVKTFSGQ THGFVHRKRE DCSPADKPYI EEARRNLIEW 240
LNKYV 245 
Gene Ontology
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. 
Interpro
 IPR002925; Dienelactn_hydro. 
Pfam
 PF01738; DLH 
SMART
  
PROSITE
  
PRINTS