UniProt Accession

 SIS1_YEAST; P25294; D6W1H0 

Genbank Protein ID

 X58460; Z71283; BK006947 

Genbank Nucleotide ID

 CAA41366.1; CAA95866.1; DAA10536.1 

Protein Name

 Protein SIS1 

Protein Synonyms/Alias

  

Gene Name

 SIS1 

Gene Synonyms/Alias

 YNL007C; N2879 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
23	SANEQELKKGYRKAA	acetylation	[1]
32	GYRKAALKYHPDKPT	acetylation	[1]
37	ALKYHPDKPTGDTEK	acetylation	[1]
44	KPTGDTEKFKEISEA	acetylation	[1]
256	LQFVIQEKSHPNFKR	acetylation	[1]
320	GQGMPTPKNPSQRGN	ubiquitination	[2]
331	QRGNLIVKYKVDYPI	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Required for nuclear migration during mitosis. It is required for the normal initiation of translation. Might mediate the dissociation of a specific protein complex of the translation machinery. Essential for viability. 

Sequence Annotation

 DOMAIN 4 70 J.
 MOD_RES 275 275 Phosphoserine.  

Keyword

 3D-structure; Cell cycle; Chaperone; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 352 AA 

Protein Sequence

Gene Ontology

 GO:0022627; C:cytosolic small ribosomal subunit; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0051082; F:unfolded protein binding; TAS:SGD.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IDA:SGD.
 GO:0006413; P:translational initiation; IMP:SGD. 

Interpro

 IPR002939; DnaJ_C.
 IPR001623; DnaJ_domain.
 IPR018253; DnaJ_domain_CS.
 IPR008971; HSP40/DnaJ_pept-bd. 

Pfam

 PF00226; DnaJ
 PF01556; DnaJ_C 

SMART

 SM00271; DnaJ 

PROSITE

 PS00636; DNAJ_1
 PS50076; DNAJ_2 

PRINTS

 PR00625; JDOMAIN.