| Tag | Content |
|---|
| CPLM ID | CPLM-009388 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Type 2 lactosamine alpha-2,3-sialyltransferase |
Protein Synonyms/Alias | CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI; ST3Gal VI; ST3GalVI; Sialyltransferase 10 |
Gene Name | St3gal6 |
Gene Synonyms/Alias | Siat10 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 250 | RFPRVFPKDQKPKHP | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 (By similarity). |
Sequence Annotation | CARBOHYD 129 129 N-linked (GlcNAc...) (Potential).
CARBOHYD 181 181 N-linked (GlcNAc...) (Potential).
CARBOHYD 295 295 N-linked (GlcNAc...) (Potential).
CARBOHYD 308 308 N-linked (GlcNAc...) (Potential).
CARBOHYD 327 327 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Glycoprotein; Glycosyltransferase; Golgi apparatus; Membrane; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 331 AA |
Protein Sequence | MKGYVVAIFL SSIFLYYVLY CILWGTNGYW FPNEEMKSKN NVKNCFKKPA FASLLRFPQF 60
YPFLCKADFV KVAATYGTNN FLLPYGVKTF ESYFRSGLSK LQSCDLVGQF DTVPCKRCVV 120
VGNGGVLKNK TLGAKIDSYD VIIRMNNGPV LGHEEEVGKR TTFRLFYPES VFSDPSHYDP 180
NTTAVLVVFK PQDLRWLMEI LIGKKINTDG FWKKPALKLI YKQYQIRILD PYIIREAAFQ 240
LLRFPRVFPK DQKPKHPTTG IIALTLAFHI CSEVHLAGFK YNFYTPDSPL HYYGNATMSL 300
MKKNAYHNLT AEQLFLKNLI KKKMVINLTQ N 331 |
Gene Ontology | GO:0030173; C:integral to Golgi membrane; IEA:InterPro. GO:0052798; F:beta-galactoside alpha-2,3-sialyltransferase activity; ISS:UniProtKB. GO:0006464; P:cellular protein modification process; ISS:UniProtKB. GO:0071354; P:cellular response to interleukin-6; ISS:UniProtKB. GO:0006664; P:glycolipid metabolic process; ISS:UniProtKB. GO:0009311; P:oligosaccharide metabolic process; ISS:UniProtKB. GO:0006486; P:protein glycosylation; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |