CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011374
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FK506-binding protein 4 
Protein Synonyms/Alias
 Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase 
Gene Name
 FPR4 
Gene Synonyms/Alias
 YLR449W; L9324.3 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
335KGKPFVFKLGQGEVIacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). 
Sequence Annotation
 DOMAIN 306 392 PPIase FKBP-type.
 MOD_RES 80 80 Phosphoserine.
 MOD_RES 82 82 Phosphoserine.  
Keyword
 Complete proteome; Isomerase; Nucleus; Phosphoprotein; Reference proteome; Rotamase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 392 AA 
Protein Sequence
MSDMLPLATY SLNVEPYSPT PALNFKIPVT IRITMAAIDP EPFDDDKKPS TLRIIKRNPE 60
LTRGEYYNQD NNDGLEEDES ESEQEADVPK RSVKSKKGKA VEQSESEDSE DENEIDDEFE 120
ECVLLTLSPK GQYQQALDIT IAPEEDVQFV VTGSYTISLT GNYVKHPFDN SSDSDEDEED 180
YYSDEESSNG EEEEEEEEED DEELSSGDDD LDDLVDASDI ESRLDELVKK DEKKKNNKKD 240
SKRKHEEDEE ESAKPAEKKQ TTKKDKKAEK VKDSEESKPK PKTKLLEGGI IIEDRVTGKG 300
PHAKKGTRVG MRYVGKLKNG KVFDKNTKGK PFVFKLGQGE VIKGWDIGVA GMAVGGERRI 360
VIPAPYAYGK QALPGIPANS ELTFDVKLVS MK 392 
Gene Ontology
 GO:0016020; C:membrane; IBA:RefGenome.
 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0005528; F:FK506 binding; IBA:RefGenome.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IDA:SGD.
 GO:0000183; P:chromatin silencing at rDNA; IMP:SGD.
 GO:0000412; P:histone peptidyl-prolyl isomerization; IDA:SGD.
 GO:0000415; P:negative regulation of histone H3-K36 methylation; IMP:SGD.
 GO:0006334; P:nucleosome assembly; IDA:SGD.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0034401; P:regulation of transcription by chromatin organization; IMP:SGD. 
Interpro
 IPR026257; FK506_BP.
 IPR023566; PPIase_FKBP.
 IPR001179; PPIase_FKBP_dom. 
Pfam
 PF00254; FKBP_C 
SMART
  
PROSITE
 PS50059; FKBP_PPIASE 
PRINTS