| Tag | Content |
|---|
| CPLM ID | CPLM-011569 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein-glutamine gamma-glutamyltransferase E |
Protein Synonyms/Alias | Transglutaminase E; TG(E); TGE; TGase E; Transglutaminase-3; TGase-3; Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain; Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain |
Gene Name | TGM3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 577 | IRITAVCKVPDESEV | acetylation | [1] |
|
Reference | [1] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G. J Cell Biol. 2011 Feb 21;192(4):615-29. [ PMID: 21339330] |
Functional Description | Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross- linking structural proteins to hardening the inner root sheath. |
Sequence Annotation | ACT_SITE 273 273 By similarity.
ACT_SITE 331 331 By similarity.
ACT_SITE 354 354 By similarity.
METAL 394 394 Calcium (By similarity).
METAL 396 396 Calcium (By similarity).
METAL 444 444 Calcium (By similarity).
METAL 449 449 Calcium (By similarity).
MOD_RES 2 2 N-acetylalanine.
MOD_RES 111 111 Phosphotyrosine.
MOD_RES 112 112 Phosphothreonine. |
Keyword | 3D-structure; Acetylation; Acyltransferase; Calcium; Complete proteome; Direct protein sequencing; Keratinization; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Transferase; Zymogen. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 693 AA |
Protein Sequence | MAALGVQSIN WQTAFNRQAH HTDKFSSQEL ILRRGQNFQV LMIMNKGLGS NERLEFIVST 60
GPYPSESAMT KAVFPLSNGS SGGWSAVLQA SNGNTLTISI SSPASAPIGR YTMALQIFSQ 120
GGISSVKLGT FILLFNPWLN VDSVFMGNHA EREEYVQEDA GIIFVGSTNR IGMIGWNFGQ 180
FEEDILSICL SILDRSLNFR RDAATDVASR NDPKYVGRVL SAMINSNDDN GVLAGNWSGT 240
YTGGRDPRSW NGSVEILKNW KKSGFSPVRY GQCWVFAGTL NTALRSLGIP SRVITNFNSA 300
HDTDRNLSVD VYYDPMGNPL DKGSDSVWNF HVWNEGWFVR SDLGPSYGGW QVLDATPQER 360
SQGVFQCGPA SVIGVREGDV QLNFDMPFIF AEVNADRITW LYDNTTGKQW KNSVNSHTIG 420
RYISTKAVGS NARMDVTDKY KYPEGSDQER QVFQKALGKL KPNTPFAATS SMGLETEEQE 480
PSIIGKLKVA GMLAVGKEVN LVLLLKNLSR DTKTVTVNMT AWTIIYNGTL VHEVWKDSAT 540
MSLDPEEEAE HPIKISYAQY EKYLKSDNMI RITAVCKVPD ESEVVVERDI ILDNPTLTLE 600
VLNEARVRKP VNVQMLFSNP LDEPVRDCVL MVEGSGLLLG NLKIDVPTLG PKEGSRVRFD 660
ILPSRSGTKQ LLADFSCNKF PAIKAMLSID VAE 693 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:UniProtKB. GO:0031234; C:extrinsic to internal side of plasma membrane; IDA:UniProtKB. GO:0005509; F:calcium ion binding; IDA:UniProtKB. GO:0019003; F:GDP binding; IDA:UniProtKB. GO:0005525; F:GTP binding; IDA:UniProtKB. GO:0003924; F:GTPase activity; IDA:UniProtKB. GO:0000287; F:magnesium ion binding; IDA:UniProtKB. GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IDA:UniProtKB. GO:0043163; P:cell envelope organization; IDA:UniProtKB. GO:0031069; P:hair follicle morphogenesis; TAS:UniProtKB. GO:0031424; P:keratinization; IEA:UniProtKB-KW. GO:0030216; P:keratinocyte differentiation; IEP:UniProtKB. GO:0018149; P:peptide cross-linking; IDA:UniProtKB. GO:0051262; P:protein tetramerization; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |