UniProt Accession

 TRI54_HUMAN; Q9BYV2; A5D8T7; Q53SY4; Q9BYV3 

Genbank Protein ID

 AJ291714; AJ291714; AC013413; CH471053; BC141807 

Genbank Nucleotide ID

 CAC32841.1; CAC32842.1; AAY24296.1; EAX00606.1; AAI41808.1 

Protein Name

 Tripartite motif-containing protein 54 

Protein Synonyms/Alias

 Muscle-specific RING finger protein; MuRF; Muscle-specific RING finger protein 3; MuRF-3; MuRF3; RING finger protein 30 

Gene Name

 TRIM54 

Gene Synonyms/Alias

 MURF; MURF3; RNF30 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
171	PTIYKRQKSELSDGI	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 May bind and stabilize microtubules during myotubes formation (By similarity). 

Sequence Annotation

 DOMAIN 271 329 COS.
 ZN_FING 26 82 RING-type.
 ZN_FING 121 163 B box-type.
 REGION 168 211 Mediates microtubule-binding and  

Keyword

 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Metal-binding; Microtubule; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 358 AA 

Protein Sequence

Gene Ontology

 GO:0005874; C:microtubule; NAS:UniProtKB.
 GO:0005875; C:microtubule associated complex; IEA:Compara.
 GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
 GO:0004871; F:signal transducer activity; NAS:UniProtKB.
 GO:0008270; F:zinc ion binding; NAS:UniProtKB.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007017; P:microtubule-based process; NAS:UniProtKB.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0007026; P:negative regulation of microtubule depolymerization; NAS:UniProtKB. 

Interpro

 IPR017903; COS_domain.
 IPR000315; Znf_B-box.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 

Pfam

 PF00643; zf-B_box 

SMART

 SM00336; BBOX
 SM00184; RING 

PROSITE

 PS51262; COS
 PS50119; ZF_BBOX
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 

PRINTS