CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039610
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Zinc finger protein 678 
Protein Synonyms/Alias
  
Gene Name
 ZNF678 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
374KRIHTGEKPYQCEECubiquitination[1]
383YQCEECGKTFNRCSHubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 580 AA 
Protein Sequence
MPGHPESRKT RRILTMLPRL VLNSFPQVIL LPNPPKVLRL QGLLAFSDVV IEFSPEEWAC 60
LDPAQRNLYR DVMFENYRNL VSLAILSYSI QDLLPEQDMK DLCQKVTLTR HRSWGLDNLH 120
LVKDWRTVNE GKGQKEYCNR LTQCSSTKSK IFQCIECGRN FSWRSILTEH KRIHTGEKPY 180
KCEECGKVFN RCSNLTKHKR IHTGEKPYKC DECGKVFNWW SQLTNHKKIH TGEKPYKCDE 240
CDKVFNWWSQ LTSHKKIHSG EKPYPCEECG KAFTQFSNLT QHKRIHTGEK PYKCKECCKA 300
FNKFSNLTQH KRIHTGEKPY KCEECGNVFN ECSHLTRHRR IHTGEKPYKC EECGKAFTQF 360
ASLTRHKRIH TGEKPYQCEE CGKTFNRCSH LSSHKRIHTG EKPYKCEECG RTFTQFSNLT 420
QHKRIHTGEK PYKCKECGKA FNKFSSLTQH RRIHTGVKPY KCEECGKVFK QCSHLTSHKR 480
IHTGEKPYKC KECGKAFYQS SILSKHKRIH TEEKPYKCEE CGKAFNQFSS LTRHKRIHTG 540
EKRYKCKECG KGFYQSSIHS KYKRIYTGEE PDKCKKCGSL 580 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS