UniProt Accession

 NKX31_HUMAN; Q99801; O15465; Q9H2P4; Q9H2P5; Q9H2P6; Q9H2P7; Q9HBG0 

Genbank Protein ID

 U91540; U80669; AF247704; AF249669; AF249670; AF249671; AF249672; BC074863; BC074864 

Genbank Nucleotide ID

 AAB68662.1; AAB38747.1; AAG09781.1; AAG39735.1; AAG39736.1; AAG39737.1; AAG39738.1; AAH74863.1; AAH74864.1 

Protein Name

 Homeobox protein Nkx-3.1 

Protein Synonyms/Alias

 Homeobox protein NK-3 homolog A 

Gene Name

 NKX3-1 

Gene Synonyms/Alias

 NKX3.1; NKX3A 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
162	AHLAKNLKLTETQVK	ubiquitination	[1]
182	RRYKTKRKQLSSELG	ubiquitination	[1, 2]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. 

Sequence Annotation

 DNA_BIND 124 183 Homeobox.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; DNA-binding; Homeobox; Nucleus; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation; Tumor suppressor; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 234 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0004882; F:androgen receptor activity; IDA:UniProtKB.
 GO:0001047; F:core promoter binding; IDA:UniProtKB.
 GO:0030284; F:estrogen receptor activity; IDA:UniProtKB.
 GO:0030331; F:estrogen receptor binding; IDA:UniProtKB.
 GO:0000988; F:protein binding transcription factor activity; IDA:UniProtKB.
 GO:0030295; F:protein kinase activator activity; IDA:UniProtKB.
 GO:0043621; F:protein self-association; IDA:UniProtKB.
 GO:0000983; F:RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IDA:BHF-UCL.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
 GO:0060442; P:branching involved in prostate gland morphogenesis; ISS:UniProtKB.
 GO:0048754; P:branching morphogenesis of an epithelial tube; ISS:UniProtKB.
 GO:0035690; P:cellular response to drug; IEP:UniProtKB.
 GO:0071456; P:cellular response to hypoxia; IDA:UniProtKB.
 GO:0071347; P:cellular response to interleukin-1; IEP:UniProtKB.
 GO:0071356; P:cellular response to tumor necrosis factor; IEP:UniProtKB.
 GO:0035907; P:dorsal aorta development; IEA:Compara.
 GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis; ISS:UniProtKB.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0008584; P:male gonad development; IEA:Compara.
 GO:0001656; P:metanephros development; IEA:Compara.
 GO:0071850; P:mitotic cell cycle arrest; IDA:UniProtKB.
 GO:0060770; P:negative regulation of epithelial cell proliferation involved in prostate gland development; ISS:UniProtKB.
 GO:0071899; P:negative regulation of estrogen receptor binding; IDA:UniProtKB.
 GO:0043569; P:negative regulation of insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.
 GO:0045930; P:negative regulation of mitotic cell cycle; IDA:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0060037; P:pharyngeal system development; IEA:Compara.
 GO:2000836; P:positive regulation of androgen secretion; IDA:UniProtKB.
 GO:0010942; P:positive regulation of cell death; IDA:UniProtKB.
 GO:0051781; P:positive regulation of cell division; IMP:BHF-UCL.
 GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.
 GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IDA:UniProtKB.
 GO:0045931; P:positive regulation of mitotic cell cycle; IMP:BHF-UCL.
 GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IDA:UniProtKB.
 GO:2001022; P:positive regulation of response to DNA damage stimulus; IDA:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0043491; P:protein kinase B signaling cascade; IMP:UniProtKB.
 GO:0033574; P:response to testosterone stimulus; ISS:UniProtKB.
 GO:0001756; P:somitogenesis; IEA:Compara. 

Interpro

 IPR017970; Homeobox_CS.
 IPR020479; Homeobox_metazoa.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like. 

Pfam

 PF00046; Homeobox 

SMART

 SM00389; HOX 

PROSITE

 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 

PRINTS

 PR00024; HOMEOBOX.