Tag | Content |
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CPLM ID | CPLM-021555 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | COP9 signalosome complex subunit 7b |
Protein Synonyms/Alias | SGN7b; Signalosome subunit 7b; JAB1-containing signalosome subunit 7b |
Gene Name | COPS7B |
Gene Synonyms/Alias | CSN7B |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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110 | EAEVTNIKKTLKATA | ubiquitination | [1] | 114 | TNIKKTLKATASSSA | ubiquitination | [1] | 150 | TKKMSKVKGLVSSRH | ubiquitination | [1] |
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Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. |
Sequence Annotation | DOMAIN 52 156 PCI. MOD_RES 2 2 N-acetylalanine. |
Keyword | Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Signalosome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 264 AA |
Protein Sequence | MKCIPYSVLL KDLEMRNLRE LEDLIIEAVY TDIIQGKLDQ RNQLLEVDFC IGRDIRKKDI 60 NNIVKTLHEW CDGCEAVLLG IEQQVLRANQ YKENHNRTQQ QVEAEVTNIK KTLKATASSS 120 AQEMEQQLAE RECPPHAEQR QPTKKMSKVK GLVSSRH 157 |
Gene Ontology | |
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SMART | |
PROSITE | |
PRINTS | |