| Tag | Content |
|---|
| CPLM ID | CPLM-017021 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Probable G-protein coupled receptor 125 |
Protein Synonyms/Alias | |
Gene Name | GPR125 |
Gene Synonyms/Alias | UNQ556/PRO1113 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 635 | PTDDSLYKLQLIAFR | ubiquitination | [1] | | 1248 | DACSTLPKSSRNFEK | ubiquitination | [1] | | 1316 | NVRTGLWKHETTV** | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Orphan receptor. |
Sequence Annotation | REPEAT 82 103 LRR 1.
REPEAT 106 127 LRR 2.
REPEAT 130 151 LRR 3.
REPEAT 154 175 LRR 4.
DOMAIN 187 237 LRRCT.
DOMAIN 242 340 Ig-like.
REPEAT 594 620 LRR 5.
DOMAIN 698 749 GPS.
MOTIF 1319 1321 PDZ-binding (Potential).
CARBOHYD 81 81 N-linked (GlcNAc...) (Potential).
CARBOHYD 98 98 N-linked (GlcNAc...) (Potential).
CARBOHYD 159 159 N-linked (GlcNAc...) (Potential).
CARBOHYD 206 206 N-linked (GlcNAc...) (Potential).
CARBOHYD 301 301 N-linked (GlcNAc...) (Potential).
CARBOHYD 332 332 N-linked (GlcNAc...) (Potential).
CARBOHYD 433 433 N-linked (GlcNAc...) (Potential).
CARBOHYD 453 453 N-linked (GlcNAc...) (Potential).
CARBOHYD 592 592 N-linked (GlcNAc...) (Potential).
CARBOHYD 652 652 N-linked (GlcNAc...) (Potential).
CARBOHYD 687 687 N-linked (GlcNAc...) (Potential).
CARBOHYD 728 728 N-linked (GlcNAc...) (Potential).
CARBOHYD 821 821 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Cell membrane; Complete proteome; G-protein coupled receptor; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transducer; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1321 AA |
Protein Sequence | MEPPGRRRGR AQPPLLLPLS LLALLALLGG GGGGGAAALP AGCKHDGRPR GAGRAAGAAE 60
GKVVCSSLEL AQVLPPDTLP NRTVTLILSN NKISELKNGS FSGLSLLERL DLRNNLISSI 120
DPGAFWGLSS LKRLDLTNNR IGCLNADIFR GLTNLVRLNL SGNLFSSLSQ GTFDYLASLR 180
SLEFQTEYLL CDCNILWMHR WVKEKNITVR DTRCVYPKSL QAQPVTGVKQ ELLTCDPPLE 240
LPSFYMTPSH RQVVFEGDSL PFQCMASYID QDMQVLWYQD GRIVETDESQ GIFVEKNMIH 300
NCSLIASALT ISNIQAGSTG NWGCHVQTKR GNNTRTVDIV VLESSAQYCP PERVVNNKGD 360
FRWPRTLAGI TAYLQCTRNT HGSGIYPGNP QDERKAWRRC DRGGFWADDD YSRCQYANDV 420
TRVLYMFNQM PLNLTNAVAT ARQLLAYTVE AANFSDKMDV IFVAEMIEKF GRFTKEEKSK 480
ELGDVMVDIA SNIMLADERV LWLAQREAKA CSRIVQCLQR IATYRLAGGA HVYSTYSPNI 540
ALEAYVIKST GFTGMTCTVF QKVAASDRTG LSDYGRRDPE GNLDKQLSFK CNVSNTFSSL 600
ALKNTIVEAS IQLPPSLFSP KQKRELRPTD DSLYKLQLIA FRNGKLFPAT GNSTNLADDG 660
KRRTVVTPVI LTKIDGVNVD THHIPVNVTL RRIAHGADAV AARWDFDLLN GQGGWKSDGC 720
HILYSDENIT TIQCYSLSNY AVLMDLTGSE LYTQAASLLH PVVYTTAIIL LLCLLAVIVS 780
YIYHHSLIRI SLKSWHMLVN LCFHIFLTCV VFVGGITQTR NASICQAVGI ILHYSTLATV 840
LWVGVTARNI YKQVTKKAKR CQDPDEPPPP PRPMLRFYLI GGGIPIIVCG ITAAANIKNY 900
GSRPNAPYCW MAWEPSLGAF YGPASFITFV NCMYFLSIFI QLKRHPERKY ELKEPTEEQQ 960
RLAANENGEI NHQDSMSLSL ISTSALENEH TFHSQLLGAS LTLLLYVALW MFGALAVSLY 1020
YPLDLVFSFV FGATSLSFSA FFVVHHCVNR EDVRLAWIMT CCPGRSSYSV QVNVQPPNSN 1080
GTNGEAPKCP NSSAESSCTN KSASSFKNSS QGCKLTNLQA AAAQCHANSL PLNSTPQLDN 1140
SLTEHSMDND IKMHVAPLEV QFRTNVHSSR HHKNRSKGHR ASRLTVLREY AYDVPTSVEG 1200
SVQNGLPKSR LGNNEGHSRS RRAYLAYRER QYNPPQQDSS DACSTLPKSS RNFEKPVSTT 1260
SKKDALRKPA VVELENQQKS YGLNLAIQNG PIKSNGQEGP LLGTDSTGNV RTGLWKHETT 1320
V 1321 |
Gene Ontology | GO:0009897; C:external side of plasma membrane; IEA:Compara. GO:0016021; C:integral to membrane; TAS:GDB. GO:0004930; F:G-protein coupled receptor activity; TAS:GDB. GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |