CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039725
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Condensin complex subunit 1 
Protein Synonyms/Alias
  
Gene Name
 NCAPD2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
73NAHLNALKMNCYALIubiquitination[1, 2]
103VDLDLGGKGKKARTKubiquitination[1, 3]
106DLGGKGKKARTKAAHubiquitination[2]
1020LLFTMLEKSPLPIVRubiquitination[1, 2, 3]
1065DPAQQVRKTAGLVMTubiquitination[1, 2]
1083LKDMVKVKGQVSEMAubiquitination[1]
1156LSYITKDKQTESLVEubiquitination[2, 3]
1164QTESLVEKLCQRFRTubiquitination[1, 2]
1243IIDEFEQKLRACHTRubiquitination[2, 3]
1256TRGLDGIKELEIGQAubiquitination[1, 2, 3, 4]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
 Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). 
Sequence Annotation
  
Keyword
 Cell cycle; Cell division; Complete proteome; DNA condensation; Mitosis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1356 AA 
Protein Sequence
MLCKRYCPSN IFHHSLELFR LPFELRGPWL CCSTLILSTA FCMVSRHSQE LPAILDDTTL 60
SGSDRNAHLN ALKMNCYALI RLLESFETMA SQTNLVDLDL GGKGKKARTK AAHGFDWEEE 120
RQPILQLLTQ LLQLDIRHLW NHSIIEEEFV SLVTGCCYRL LENPTINHQK NRPTREAITH 180
LLGVALTRYN HMLSATVKII QMLQHFEHLA PVLVAAVSLW ATDYGMKSIV GEIVREIGQK 240
CPQELSRDPS GTKGFAAFLT ELAERVPAIL MSSMCILLDH LDGENYMMRN AVLAAMAEMV 300
LQVLSGDQLE AAARDTRDQF LDTLQAHGHD VNSFVRSRVL QLFTRIVQQK ALPLTRFQAV 360
VALAVGRLAD KSVLVCKNAI QLLASFLANN PFSCKLSDAD LAGPLQKETQ KLQEMRAQRR 420
TAAASAVLDP EEEWEAMLPE LKSTLQQLLQ LPQGEEEIPE QIANTETTED VKGRIYQLLA 480
KASYKKAIIL TREATGHFQE SEPFSHIDPE ESEETRLLNI LGLIFKGPAA STQEKNPRES 540
TGNMVTGQTV CKNKPNMSDP EESRGNDELV KQEMLVQYLQ DAYSFSRKIT EAIGIISKMM 600
YENTTTVVQE VIEFFVMVFQ FGVPQALFGV RRMLPLIWSK EPGVREAVLN AYRQLYLNPK 660
GDSARAKAQA LIQNLSLLLV DASVGTIQCL EEILCEFVQK DELKPAVTQL LWERATEKVA 720
CCPLERCSSV MLLGMMARGK PEIVGSNLDT LVSIGLDEKF PQDYRLAQQV CHAIANISDR 780
RKPSLGKRHP PFRLPQEHRL FERLRETVTK GFVHPDPLWI PFKEVAVTLI YQLAEGPEVI 840
CAQILQGCAK QALEKLEEKR TSQEDPKESP AMLPTFLLMN LLSLAGDVAL QQLVHLEQAV 900
SGELCRRRVL REEQEHKTKD PKEKNTSSET TMEEELGLVG ATADDTEAEL IRGICEMELL 960
DGKQTLAAFV PLLLKVCNNP GLYSNPDLSA AASLALGKFC MISATFCDSQ LRLLFTMLEK 1020
SPLPIVRSNL MVATGDLAIR FPNLVDPWTP HLYARLRDPA QQVRKTAGLV MTHLILKDMV 1080
KVKGQVSEMA VLLIDPEPQI AALAKNFFNE LSHKGNAIYN LLPDIISRLS DPELGVEEEP 1140
FHTIMKQLLS YITKDKQTES LVEKLCQRFR TSRTERQQRD LAYCVSQLPL TERGLRKMLD 1200
NFDCFGDKLS DESIFSAFLS VVGKLRRGAK PEGKAIIDEF EQKLRACHTR GLDGIKELEI 1260
GQAGSQRAPS AKKPSTGSRY QPLASTASDN DFVTPEPRRT TRRHPNTQQR ASKKKPKVVF 1320
SSDESSEEDL SAEMTEDETP KKTTPILRAS ARRHRS 1356 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007076; P:mitotic chromosome condensation; IEA:InterPro. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR026971; CND1/NCAPD3.
 IPR007673; Condensin_cplx_su1.
 IPR024324; Condensin_cplx_su1_N. 
Pfam
 PF12922; Cnd1_N 
SMART
  
PROSITE
  
PRINTS