CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004975
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine--pyruvate aminotransferase 
Protein Synonyms/Alias
 SPT; Alanine--glyoxylate aminotransferase; AGT 
Gene Name
 AGXT 
Gene Synonyms/Alias
 AGT1; SPAT 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
228SFSDKAKKKMYSRKTmethylation[1]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
  
Sequence Annotation
 BINDING 360 360 Substrate.
 MOD_RES 209 209 N6-(pyridoxal phosphate)lysine.  
Keyword
 3D-structure; Aminotransferase; Complete proteome; Disease mutation; Mitochondrion; Peroxisome; Polymorphism; Pyridoxal phosphate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 392 AA 
Protein Sequence
MASHKLLVTP PKALLKPLSI PNQLLLGPGP SNLPPRIMAA GGLQMIGSMS KDMYQIMDEI 60
KEGIQYVFQT RNPLTLVISG SGHCALEAAL VNVLEPGDSF LVGANGIWGQ RAVDIGERIG 120
ARVHPMTKDP GGHYTLQEVE EGLAQHKPVL LFLTHGESST GVLQPLDGFG ELCHRYKCLL 180
LVDSVASLGG TPLYMDRQGI DILYSGSQKA LNAPPGTSLI SFSDKAKKKM YSRKTKPFSF 240
YLDIKWLANF WGCDDQPRMY HHTIPVISLY SLRESLALIA EQGLENSWRQ HREAAAYLHG 300
RLQALGLQLF VKDPALRLPT VTTVAVPAGY DWRDIVSYVI DHFDIEIMGG LGPSTGKVLR 360
IGLLGCNATR ENVDRVTEAL RAALQHCPKK KL 392 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005782; C:peroxisomal matrix; IDA:UniProtKB.
 GO:0008453; F:alanine-glyoxylate transaminase activity; IDA:UniProtKB.
 GO:0016597; F:amino acid binding; IDA:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0030170; F:pyridoxal phosphate binding; IDA:UniProtKB.
 GO:0004760; F:serine-pyruvate transaminase activity; IEA:EC.
 GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.
 GO:0019265; P:glycine biosynthetic process, by transamination of glyoxylate; IDA:UniProtKB.
 GO:0009436; P:glyoxylate catabolic process; IDA:UniProtKB.
 GO:0042853; P:L-alanine catabolic process; IDA:UniProtKB.
 GO:0019448; P:L-cysteine catabolic process; IDA:UniProtKB.
 GO:0046724; P:oxalic acid secretion; IEA:Compara.
 GO:0006625; P:protein targeting to peroxisome; IMP:HGNC.
 GO:0042866; P:pyruvate biosynthetic process; IEA:Compara.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara. 
Interpro
 IPR000192; Aminotrans_V/Cys_dSase.
 IPR020578; Aminotrans_V_PyrdxlP_BS.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR024169; SP_NH2Trfase/AEP_transaminase. 
Pfam
 PF00266; Aminotran_5 
SMART
  
PROSITE
 PS00595; AA_TRANSFER_CLASS_5 
PRINTS