UniProt Accession

 ISK1_RAT; P09655; P13072 

Genbank Protein ID

 X59696; M22162; M35299; M35300; M27882; D11321 

Genbank Nucleotide ID

 CAA42217.1; AAA41629.1; AAA74479.1; AAA41977.1; AAA41975.1; BAA01944.1 

Protein Name

 Pancreatic secretory trypsin inhibitor 

Protein Synonyms/Alias

 Cholecystokinin-releasing peptide; Monitor peptide; PSTI-I; Serine protease inhibitor Kazal-type 1 

Gene Name

 Spink1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
66	SLCFENRKFGTSIHI	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. 

Sequence Annotation

 DOMAIN 26 79 Kazal-like.
 DISULFID 32 61 By similarity.
 DISULFID 39 58 By similarity.
 DISULFID 47 79 By similarity.  

Keyword

 Complete proteome; Direct protein sequencing; Disulfide bond; Protease inhibitor; Reference proteome; Secreted; Serine protease inhibitor; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 79 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; TAS:RGD.
 GO:0004866; F:endopeptidase inhibitor activity; IMP:RGD.
 GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
 GO:0045861; P:negative regulation of proteolysis; IMP:RGD. 

Interpro

 IPR002350; Kazal_dom. 

Pfam

 PF00050; Kazal_1 

SMART

 SM00280; KAZAL 

PROSITE

 PS00282; KAZAL_1
 PS51465; KAZAL_2 

PRINTS