UniProt Accession

 RSC7_YEAST; P32832; D6VZR4 

Genbank Protein ID

 M98434; Z49259; BK006946 

Genbank Nucleotide ID

 AAA34817.1; CAA89238.1; DAA09988.1 

Protein Name

 Chromatin structure-remodeling complex subunit RSC7 

Protein Synonyms/Alias

 Nuclear protein localization protein 6; Remodel the structure of chromatin complex subunit 7 

Gene Name

 NPL6 

Gene Synonyms/Alias

 RSC7; YMR091C; YM9582.16C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
259	KGNVIEGKLAGDPID	acetylation	[1]
267	LAGDPIDKSARALET	acetylation	[1]
430	TEQQNFEKCNEYI**	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. Together with HTL1, LDB7, RSC3, RSC30 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity. Acidic protein important for nuclear protein localization. 

Sequence Annotation

 REGION 248 435 Functional region; able to complement all
 MOD_RES 86 86 Phosphoserine.  

Keyword

 Chromatin regulator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 435 AA 

Protein Sequence

Gene Ontology

 GO:0016586; C:RSC complex; IDA:SGD.
 GO:0043044; P:ATP-dependent chromatin remodeling; IDA:SGD.
 GO:0006337; P:nucleosome disassembly; IDA:SGD.
 GO:0006606; P:protein import into nucleus; IMP:SGD.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006974; P:response to DNA damage stimulus; IMP:SGD.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; IDA:SGD. 

Interpro

 IPR013933; CRC_Rsc7/Swp82. 

Pfam

 PF08624; CRC_subunit 

SMART

  

PROSITE

  

PRINTS