CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018684
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Keratin, type II cytoskeletal 5 
Protein Synonyms/Alias
 Cytokeratin-5; CK-5; Keratin-5; K5; Type-II keratin Kb5 
Gene Name
 Krt5 
Gene Synonyms/Alias
 Krt2-5 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
188RFLEQQNKVLDTKWAubiquitination[1]
Reference
 [1] BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
 Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
 Nature. 2012 Nov 22;491(7425):618-21. [PMID: 23086144
Functional Description
  
Sequence Annotation
 REGION 1 161 Head.
 REGION 162 471 Rod.
 REGION 162 197 Coil 1A.
 REGION 198 216 Linker 1.
 REGION 217 309 Coil 1B.
 REGION 310 332 Linker 12.
 REGION 333 471 Coil 2.
 REGION 472 580 Tail.
 MOD_RES 21 21 Phosphoserine.
 MOD_RES 61 61 Phosphoserine.
 MOD_RES 72 72 Phosphoserine.  
Keyword
 Coiled coil; Complete proteome; Direct protein sequencing; Intermediate filament; Keratin; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 580 AA 
Protein Sequence
MSRQSSVSFR SGGSRSFSAA SAITPSVSRT SFSSVSRSGG GGGGRISLGG ACGAGGYGSR 60
SLYNVGGSKR ISYSSGGGSF RNQFGAGGFG FGGGAGSGFG FGGGAGSGFG FGGGAGFGGG 120
YGGAGFPVCP PGGIQEVTVN QNLLTPLNLQ IDPTIQRVRT EEREQIKTLN NKFASFIDKV 180
RFLEQQNKVL DTKWALLQEQ GTKTIKQNLD PLFEQYINNL RRQLDGVLGE RGRLDSELRN 240
MQDLVEDYKN KYEDEINKRT TAENEFVMLK KDVDAAYMNK VELEARVDAL MDEINFMKMF 300
FDAELSQMQT HVSDTSVVLS MDNNRSLDLD SIIAEVKAQY EDIANRSRTE AESWYQTKYE 360
ELQQTAGRHG DDLRNTKHEI SEMNRMIQRL RSEIDNVKKQ CANLQNAIAE AEQRGELALK 420
DARNKLTELE EALQKAKQDM ARLLREYQEL MNTKLALDVE IATYRKLLEG EECRLSGEGV 480
GPVNISVVTN SVSSGYGGGS SIGVGSGFGG GLGSGFAGGL GPRFTRGGGG LGLGSGLSVG 540
GSGFSAGSSQ GGMSFGSGGG SGSSVKFVST TSSSRRSFKS 580 
Gene Ontology
 GO:0045095; C:keratin filament; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005198; F:structural molecule activity; IEA:InterPro. 
Interpro
 IPR016044; F.
 IPR001664; IF.
 IPR018039; Intermediate_filament_CS.
 IPR003054; Keratin_II. 
Pfam
 PF00038; Filament 
SMART
  
PROSITE
 PS00226; IF 
PRINTS
 PR01276; TYPE2KERATIN.