CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028995
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1) 
Protein Synonyms/Alias
 Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1), isoform CRA_e; cDNA FLJ77333, highly similar to Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1b, mRNA 
Gene Name
 RAC1 
Gene Synonyms/Alias
 hCG_14926; tcag7.839 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
135PIILVGTKLDLRDDKubiquitination[1]
152IEKLKEKKLTPITYPubiquitination[1]
166PQGLAMAKEIGAVKYubiquitination[1]
172AKEIGAVKYLECSALubiquitination[1]
185ALTQRGLKTVFDEAIubiquitination[1]
202VLCPPPVKKRKRKCLubiquitination[1]
203LCPPPVKKRKRKCLLubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 GTP-binding; Membrane; Nucleotide-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 211 AA 
Protein Sequence
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG 60
QEDYDRLRPL SYPQTVGETY GKDITSRGKD KPIADVFLIC FSLVSPASFE NVRAKWYPEV 120
RHHCPNTPII LVGTKLDLRD DKDTIEKLKE KKLTPITYPQ GLAMAKEIGA VKYLECSALT 180
QRGLKTVFDE AIRAVLCPPP VKKRKRKCLL L 211 
Gene Ontology
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:Compara.
 GO:0019897; C:extrinsic to plasma membrane; IEA:Compara.
 GO:0000139; C:Golgi membrane; IEA:Compara.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0001891; C:phagocytic cup; IEA:Compara.
 GO:0032587; C:ruffle membrane; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:Compara.
 GO:0007015; P:actin filament organization; IEA:Compara.
 GO:0048532; P:anatomical structure arrangement; IEA:Compara.
 GO:0002093; P:auditory receptor cell morphogenesis; IEA:Compara.
 GO:0007411; P:axon guidance; IEA:Compara.
 GO:0045453; P:bone resorption; IEA:Compara.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0045216; P:cell-cell junction organization; IEA:Compara.
 GO:0021799; P:cerebral cortex radially oriented cell migration; IEA:Compara.
 GO:0090103; P:cochlea morphogenesis; IEA:Compara.
 GO:0048813; P:dendrite morphogenesis; IEA:Compara.
 GO:0071542; P:dopaminergic neuron differentiation; IEA:Compara.
 GO:0021831; P:embryonic olfactory bulb interneuron precursor migration; IEA:Compara.
 GO:0043652; P:engulfment of apoptotic cell; IEA:Compara.
 GO:0003382; P:epithelial cell morphogenesis; IEA:Compara.
 GO:0006972; P:hyperosmotic response; IEA:Compara.
 GO:0002551; P:mast cell chemotaxis; IEA:Compara.
 GO:0030838; P:positive regulation of actin filament polymerization; IEA:Compara.
 GO:0045740; P:positive regulation of DNA replication; IEA:Compara.
 GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IEA:Compara.
 GO:0030334; P:regulation of cell migration; IEA:Compara.
 GO:0097178; P:ruffle assembly; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:Compara.
 GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:Compara.
 GO:0060071; P:Wnt receptor signaling pathway, planar cell polarity pathway; IEA:Compara. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003578; Small_GTPase_Rho. 
Pfam
 PF00071; Ras 
SMART
 SM00174; RHO 
PROSITE
 PS51420; RHO 
PRINTS
 PR00449; RASTRNSFRMNG.