CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018414
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 
Protein Synonyms/Alias
 Polymyxin resistance protein PmrH; UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase; UDP-Ara4O aminotransferase; UDP-4-amino-4-deoxy-L-arabinose aminotransferase 
Gene Name
 arnB 
Gene Synonyms/Alias
 pbgP; pbgP1; pmrH; STM2297 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
202DNPQFADKLRSLKFHacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Catalyzes the conversion of UDP-4-keto-arabinose (UDP- Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity). 
Sequence Annotation
 MOD_RES 182 182 N6-(pyridoxal phosphate)lysine.  
Keyword
 3D-structure; Aminotransferase; Antibiotic resistance; Complete proteome; Lipid A biosynthesis; Lipid biosynthesis; Lipid metabolism; Lipopolysaccharide biosynthesis; Pyridoxal phosphate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 379 AA 
Protein Sequence
MSDFLPFSRP AMGAEELAAV KTVLDSGWIT TGPKNQELEA AFCRLTGNQY AVAVSSATAG 60
MHIALMALGI GEGDEVITPS MTWVSTLNMI VLLGANPVMV DVDRDTLMVT PEHIEAAITP 120
QTKAIIPVHY AGAPADLDAI YALGERYGIP VIEDAAHATG TSYKGRHIGA RGTAIFSFHA 180
IKNITCAEGG IVVTDNPQFA DKLRSLKFHG LGVDAWDRQS GGRAPQAEVL APGYKYNLPD 240
LNAAIALAQL QKLDALNARR AAIAAQYHQA MADLPFQPLS LPSWEHIHAW HLFIIRVDEA 300
RCGITRDALM ASLKTKGIGT GLHFRAAHTQ KYYRERFPTL TLPDTEWNSE RICSLPLFPD 360
MTESDFDRVI TALHQIAGQ 379 
Gene Ontology
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0008483; F:transaminase activity; IEA:HAMAP.
 GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-KW.
 GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW. 
Interpro
 IPR022850; ArnB_NH2Trfase.
 IPR000653; DegT/StrS_aminotransferase.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF01041; DegT_DnrJ_EryC1 
SMART
  
PROSITE
  
PRINTS