CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032220
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Katanin p60 ATPase-containing subunit A1 
Protein Synonyms/Alias
  
Gene Name
 KATNA1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
51KDTYLQQKWQQVWQEubiquitination[1]
71KHVKDIMKTLESFKLubiquitination[2]
181VTEPETNKFDSTGYDubiquitination[1]
218IADLVEAKKLLKEAVubiquitination[1]
219ADLVEAKKLLKEAVVubiquitination[3]
236MWMPEFFKGIRRPWKubiquitination[3]
260TGKTLLAKAVATECKubiquitination[3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 280 AA 
Protein Sequence
MSLLMISENV KLAREYALLG NYDSAMVYYQ GVLDQMNKYL YSVKDTYLQQ KWQQVWQEIN 60
VEAKHVKDIM KTLESFKLDS TPLKAAQHDL PASEGEVWSM PVPVERRPSP GPRKRQSSQY 120
SDPKSHGNRP STTVRVHRSS AQNVHNDRGK AVRCREKKEQ NKGREEKNKS PAAVTEPETN 180
KFDSTGYDKD LVEALERDII SQNPNVRWDD IADLVEAKKL LKEAVVLPMW MPEFFKGIRR 240
PWKGVLMVGP PGTGKTLLAK AVATECKTTF FNVSSSTLTS 280 
Gene Ontology
 GO:0030424; C:axon; IEA:Compara.
 GO:0005813; C:centrosome; IDA:HPA.
 GO:0030426; C:growth cone; IEA:Compara.
 GO:0005811; C:lipid particle; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0016887; F:ATPase activity; IEA:Compara.
 GO:0031122; P:cytoplasmic microtubule organization; IEA:Compara.
 GO:0001578; P:microtubule bundle formation; IEA:Compara.
 GO:0051013; P:microtubule severing; IEA:Compara.
 GO:0010977; P:negative regulation of neuron projection development; IEA:Compara.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0008104; P:protein localization; IEA:Compara. 
Interpro
 IPR003959; ATPase_AAA_core.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00004; AAA 
SMART
  
PROSITE
  
PRINTS