CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002430
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 T-protein 
Protein Synonyms/Alias
 Chorismate mutase; CM; Prephenate dehydrogenase; PDH 
Gene Name
 tyrA 
Gene Synonyms/Alias
 b2600; JW2581 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
17DQIDEVDKALLNLLAacetylation[1]
25ALLNLLAKRLELVAEacetylation[1]
37VAEVGEVKSRFGLPIacetylation[1]
89SYSSENDKGFKTLCPacetylation[1]
92SENDKGFKTLCPSLRacetylation[1]
116QMGRLFEKMLTLSGYacetylation[1]
167GKLPPLPKDCILVDLacetylation[1]
318ERNLALIKRYYKRFGacetylation[1]
345AFIDSFRKVEHWFGDacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
  
Sequence Annotation
 DOMAIN 1 90 Chorismate mutase.
 DOMAIN 99 361 Prephenate/arogenate dehydrogenase.  
Keyword
 Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; Cytoplasm; Isomerase; Multifunctional enzyme; NAD; Oxidoreductase; Reference proteome; Tyrosine biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 373 AA 
Protein Sequence
MVAELTALRD QIDEVDKALL NLLAKRLELV AEVGEVKSRF GLPIYVPERE ASMLASRRAE 60
AEALGVPPDL IEDVLRRVMR ESYSSENDKG FKTLCPSLRP VVIVGGGGQM GRLFEKMLTL 120
SGYQVRILEQ HDWDRAADIV ADAGMVIVSV PIHVTEQVIG KLPPLPKDCI LVDLASVKNG 180
PLQAMLVAHD GPVLGLHPMF GPDSGSLAKQ VVVWCDGRKP EAYQWFLEQI QVWGARLHRI 240
SAVEHDQNMA FIQALRHFAT FAYGLHLAEE NVQLEQLLAL SSPIYRLELA MVGRLFAQDP 300
QLYADIIMSS ERNLALIKRY YKRFGEAIEL LEQGDKQAFI DSFRKVEHWF GDYAQRFQSE 360
SRVLLRQAND NRQ 373 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004106; F:chorismate mutase activity; IDA:EcoCyc.
 GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
 GO:0008977; F:prephenate dehydrogenase activity; IDA:EcoCyc.
 GO:0046417; P:chorismate metabolic process; IEA:InterPro.
 GO:0009094; P:L-phenylalanine biosynthetic process; IDA:EcoCyc.
 GO:0006571; P:tyrosine biosynthetic process; IDA:EcoCyc. 
Interpro
 IPR008927; 6-PGluconate_DH_C-like.
 IPR008244; Chor_mut/prephenate_DH_T.
 IPR002701; Chorismate_mutase.
 IPR020822; Chorismate_mutase_type_II.
 IPR011277; CM_T.
 IPR016040; NAD(P)-bd_dom.
 IPR003099; Prephen_DH. 
Pfam
 PF01817; CM_2
 PF02153; PDH 
SMART
 SM00830; CM_2 
PROSITE
 PS51168; CHORISMATE_MUT_2
 PS51176; PDH_ADH 
PRINTS