UniProt Accession

 RIT1_HUMAN; Q92963; B4DQE8; O00646; O00720; Q5VY89; Q5VY90 

Genbank Protein ID

 U71203; Y07566; U78165; AF084462; AF493923; AK298768; AK314239; CR407639; AL139128; AL355388; AL355388; AL139128; CH471121; BC104186; BC104187 

Genbank Nucleotide ID

 AAB42213.1; CAA68851.1; AAB64246.1; AAD13021.1; AAM12637.1; BAG60910.1; BAG36908.1; CAG28567.1; CAH69943.1; CAH69943.1; CAH72621.1; CAH72621.1; EAW53024.1; AAI04187.1; AAI04188.1 

Protein Name

 GTP-binding protein Rit1 

Protein Synonyms/Alias

 Ras-like protein expressed in many tissues; Ras-like without CAAX protein 1 

Gene Name

 RIT1 

Gene Synonyms/Alias

 RIBB; RIT; ROC1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
135	PVVLVGNKSDLKQLR	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation. 

Sequence Annotation

 NP_BIND 28 35 GTP (By similarity).
 NP_BIND 75 79 GTP (By similarity).
 NP_BIND 134 137 GTP (By similarity).  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; GTP-binding; Membrane; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 219 AA 

Protein Sequence

Gene Ontology

 GO:0005886; C:plasma membrane; TAS:ProtInc.
 GO:0005516; F:calmodulin binding; TAS:ProtInc.
 GO:0005525; F:GTP binding; TAS:ProtInc.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 

Pfam

 PF00071; Ras 

SMART

 SM00173; RAS 

PROSITE

 PS51421; RAS 

PRINTS

 PR00449; RASTRNSFRMNG.