UniProt Accession

 PA1B3_HUMAN; Q15102; Q53X88 

Genbank Protein ID

 D63391; CR407626; AC006486; CH471126; BC003016; BC007863 

Genbank Nucleotide ID

 BAA09706.1; CAG28554.1; AAD11989.1; EAW57122.1; AAH03016.1; AAH07863.1 

Protein Name

 Platelet-activating factor acetylhydrolase IB subunit gamma 

Protein Synonyms/Alias

 PAF acetylhydrolase 29 kDa subunit; PAF-AH 29 kDa subunit; PAF-AH subunit gamma; PAFAH subunit gamma 

Gene Name

 PAFAH1B3 

Gene Synonyms/Alias

 PAFAHG 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
10	GEENPASKPTPVQDV	ubiquitination	[1, 2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain. 

Sequence Annotation

 ACT_SITE 47 47 By similarity.
 ACT_SITE 192 192 By similarity.
 ACT_SITE 195 195 By similarity.
 MOD_RES 2 2 N-acetylserine.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Lipid degradation; Lipid metabolism; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 231 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0003847; F:1-alkyl-2-acetylglycerophosphocholine esterase activity; IEA:EC.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
 GO:0006629; P:lipid metabolic process; TAS:ProtInc.
 GO:0007399; P:nervous system development; TAS:ProtInc.
 GO:0007283; P:spermatogenesis; IEA:Compara. 

Interpro

 IPR013831; SGNH_hydro-type_esterase_dom. 

Pfam

  

SMART

  

PROSITE

 PS01098; LIPASE_GDSL_SER 

PRINTS