CPLM-019636

Genbank Nucleotide ID

Protein Synonyms/Alias

DNA cross-link repair 1C protein; Protein A-SCID; SNM1 homolog C; hSNM1C; SNM1-like protein

ARTEMIS; ASCID; SCIDA; SNM1C

Homo sapiens (Human)

Position	Peptide	Type	References
157	LHSGGRVKDIQSVYL	ubiquitination	[1]
260	IHACRHPKAEEYFQW	ubiquitination	[1]
683	TGESIAVKKRKCSLL	acetylation	[2]

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[2] Regulation of cellular metabolism by protein lysine acetylation.
Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]

Functional Description

Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ.

MOD_RES 645 645 Phosphoserine; by ATM.

3D-structure; Adaptive immunity; Alternative splicing; Complete proteome; Disease mutation; DNA damage; DNA recombination; DNA repair; Endonuclease; Exonuclease; Hydrolase; Immunity; Magnesium; Nuclease; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; SCID.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0008409; F:5'-3' exonuclease activity; IDA:MGI.
GO:0000014; F:single-stranded DNA specific endodeoxyribonuclease activity; IDA:MGI.
GO:0030183; P:B cell differentiation; IEA:Compara.
GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
GO:0006302; P:double-strand break repair; IEA:Compara.
GO:0010212; P:response to ionizing radiation; IEA:Compara.
GO:0000723; P:telomere maintenance; IEA:Compara.

IPR001279; Beta-lactamas-like.
IPR011084; DRMBL.

SM00849; Lactamase_B