UniProt Accession

 IVD_RAT; P12007 

Genbank Protein ID

 J05031; BC088401; M19867 

Genbank Nucleotide ID

 AAA41454.1; AAH88401.1; AAA41459.1 

Protein Name

 Isovaleryl-CoA dehydrogenase, mitochondrial 

Protein Synonyms/Alias

 IVD 

Gene Name

 Ivd 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
56	QLRHTISKFVQENLA	acetylation	[1]
65	VQENLAPKAQEIDQS	acetylation	[1]
76	IDQSNDFKNLREFWK	acetylation	[1]
149	GNEAQKEKYLPKLIS	acetylation	[1]
183	SMRLKAEKKGDHYVL	acetylation	[1]
239	MPGFSTSKKLDKLGM	acetylation	[1]
240	PGFSTSKKLDKLGMR	acetylation	[1]
243	STSKKLDKLGMRGSN	acetylation	[1]
316	VREAFGQKIGQFQLM	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

  

Sequence Annotation

 NP_BIND 163 172 FAD (By similarity).
 NP_BIND 196 198 FAD (By similarity).
 NP_BIND 378 382 FAD (By similarity).
 NP_BIND 407 409 FAD (By similarity).
 REGION 220 221 Substrate binding (By similarity).
 REGION 282 285 Substrate binding (By similarity).
 REGION 405 406 Substrate binding (By similarity).
 ACT_SITE 284 284 Proton acceptor (By similarity).
 BINDING 172 172 Substrate; via carbonyl oxygen (By
 BINDING 275 275 Substrate (By similarity).
 BINDING 310 310 FAD (By similarity).
 BINDING 321 321 FAD (By similarity).
 MOD_RES 76 76 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; FAD; Flavoprotein; Mitochondrion; Oxidoreductase; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 424 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IDA:BHF-UCL.
 GO:0031966; C:mitochondrial membrane; IDA:BHF-UCL.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0008470; F:isovaleryl-CoA dehydrogenase activity; IDA:BHF-UCL.
 GO:0033539; P:fatty acid beta-oxidation using acyl-CoA dehydrogenase; IC:BHF-UCL.
 GO:0006552; P:leucine catabolic process; IDA:BHF-UCL.
 GO:0051260; P:protein homooligomerization; TAS:RGD. 

Interpro

 IPR006089; Acyl-CoA_DH_CS.
 IPR006092; Acyl-CoA_DH_N.
 IPR006090; Acyl-CoA_Oxase/DH_1.
 IPR006091; Acyl-CoA_Oxase/DH_cen-dom.
 IPR009075; AcylCo_DH/oxidase_C.
 IPR013786; AcylCoA_DH/ox_N.
 IPR009100; AcylCoA_DH/oxidase. 

Pfam

 PF00441; Acyl-CoA_dh_1
 PF02770; Acyl-CoA_dh_M
 PF02771; Acyl-CoA_dh_N 

SMART

  

PROSITE

 PS00072; ACYL_COA_DH_1
 PS00073; ACYL_COA_DH_2 

PRINTS