CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022012
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hermansky-Pudlak syndrome 4 protein 
Protein Synonyms/Alias
 Light-ear protein homolog 
Gene Name
 HPS4 
Gene Synonyms/Alias
 KIAA1667 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
697FSLSGKAKQKLLKHGubiquitination[1]
702KAKQKLLKHGVNLL*ubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May function in the pathway of organelle biogenesis. 
Sequence Annotation
 MOD_RES 355 355 Phosphoserine.  
Keyword
 Albinism; Alternative splicing; Complete proteome; Hermansky-Pudlak syndrome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 708 AA 
Protein Sequence
MATSTSTEAK SASWWNYFFL YDGSKVKEEG DPTRAGICYF YPSQTLLDQQ ELLCGQIAGV 60
VRCVSDISDS PPTLVRLRKL KFAIKVDGDY LWVLGCAVEL PDVSCKRFLD QLVGFFNFYN 120
GPVSLAYENC SQEELSTEWD TFIEQILKNT SDLHKIFNSL WNLDQTKVEP LLLLKAARIL 180
QTCQRSPHIL AGCILYKGLI VSTQLPPSLT AKVLLHRTAP QEQRLPTGED APQEHGAALP 240
PNVQIIPVFV TKEEAISLHE FPVEQMTRSL ASPAGLQDGS AQHHPKGGST SALKENATGH 300
VESMAWTTPD PTSPDEACPD GRKENGCLSG HDLESIRPAG LHNSARGEVL GLSSSLGKEL 360
VFLQEELDLS EIHIPEAQEV EMASGHFAFL HVPVPDGRAP YCKASLSASS SLEPTPPEDT 420
AISSLRPPSA PEMLTQHGAQ EQLEDHPGHS SQAPIPRADP LPRRTRRPLL LPRLDPGQRG 480
NKLPTGEQGL DEDVDGVCES HAAPGLECSS GSANCQGAGP SADGISSRLT PAESCMGLVR 540
MNLYTHCVKG LVLSLLAEEP LLGDSAAIEE VYHSSLASLN GLEVHLKETL PRDEAASTSS 600
TYNFTHYDRI QSLLMANLPQ VATPQDRRFL QAVSLMHSEF AQLPALYEMT VRNASTAVYA 660
CCNPIQETYF QQLAPAARSS GFPNPQDGAF SLSGKAKQKL LKHGVNLL 708 
Gene Ontology
 GO:0005764; C:lysosome; IDA:UniProtKB.
 GO:0042470; C:melanosome; IDA:UniProtKB.
 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0042827; C:platelet dense granule; IDA:UniProtKB.
 GO:0007596; P:blood coagulation; IEA:Compara.
 GO:0007599; P:hemostasis; TAS:UniProtKB.
 GO:0007040; P:lysosome organization; IDA:UniProtKB.
 GO:0030318; P:melanocyte differentiation; IEA:Compara.
 GO:0048075; P:positive regulation of eye pigmentation; TAS:UniProtKB.
 GO:0050821; P:protein stabilization; IPI:UniProtKB.
 GO:0006605; P:protein targeting; IDA:UniProtKB. 
Interpro
 IPR026091; HPS4. 
Pfam
  
SMART
  
PROSITE
  
PRINTS