CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042325
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 ATPase family AAA domain-containing protein 3A 
Protein Synonyms/Alias
  
Gene Name
 ATAD3A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
121ARAQYQDKLARQRYEacetylation[1]
121ARAQYQDKLARQRYEubiquitination[2, 3]
344YGPPGTGKTLFAKKLubiquitination[3, 4]
380EGVTAMHKLFDWANTubiquitination[4]
410LRKRATEKISEDLRAubiquitination[1, 3]
477LVRMYFDKYVLKPATacetylation[1, 5, 6]
481YFDKYVLKPATEGKQacetylation[1, 6]
487LKPATEGKQRLKLAQubiquitination[3]
559QQKMCWLKAEGPGRGubiquitination[4]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 572 AA 
Protein Sequence
XGALALAAPR RCRQPLPGRD CAPGAPPAGA VSRAGRIGLF PSPVCTSAAV RSGSGYAKDA 60
LNLAQMQEQT LQLEQQSKLK EYEAAVEQLK SEQIRAQAEE RRKTLSEETR QHQARAQYQD 120
KLARQRYEDQ LKQQQLLNEE NLRKQEESVQ KQEAMRRATV EREMELRHKN EMLRVEAEAR 180
ARAKAERENA DIIREQIRLK AAEHRQTVLE SIRTAGTLFG EGFRAFVTDW DKVTATVAGL 240
TLLAVGVYSA KNATLVAGRF IEARLGKPSL VRETSRITVL EALRHPIQVS RRLLSRPQDA 300
LEGVVLSPSL EARVRDIAIA TRNTKKNRSL YRNILMYGPP GTGKTLFAKK LALHSGMDYA 360
IMTGGDVAPM GREGVTAMHK LFDWANTSRR GLLLFVDEAD AFLRKRATEK ISEDLRATLN 420
AFLYRTGQHS NKFMLVLASN QPEQFDWAIN DRINEMVHFD LPGQEERERL VRMYFDKYVL 480
KPATEGKQRL KLAQFDYGRK CSEVARLTEG MSGREIAQLA VSWQATAYAS EDGVLTEAMM 540
DTRVQDAVQQ HQQKMCWLKA EGPGRGDEPS PS 572 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR021911; DUF3523.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00004; AAA
 PF12037; DUF3523 
SMART
 SM00382; AAA 
PROSITE
  
PRINTS