UniProt Accession

 MTNB_MOUSE; Q9WVQ5; Q8BP46 

Genbank Protein ID

 AB028863; AK077705; AK145450; BC028434 

Genbank Nucleotide ID

 BAA78906.1; BAC36968.1; BAE26445.1; AAH28434.1 

Protein Name

 Methylthioribulose-1-phosphate dehydratase 

Protein Synonyms/Alias

 MTRu-1-P dehydratase; APAF1-interacting protein; Monocyte/macrophage protein 19 

Gene Name

 Apip 

Gene Synonyms/Alias

 Mmrp19 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
20	RPCGAQDKEHPRFLI	acetylation	[1]
170	IENTPEEKDLKERMA	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. 

Sequence Annotation

 METAL 114 114 Zinc (By similarity).
 METAL 116 116 Zinc (By similarity).  

Keyword

 Amino-acid biosynthesis; Apoptosis; Complete proteome; Cytoplasm; Lyase; Metal-binding; Methionine biosynthesis; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 241 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0046570; F:methylthioribulose 1-phosphate dehydratase activity; IEA:HAMAP.
 GO:0008270; F:zinc ion binding; IEA:HAMAP.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0019284; P:L-methionine biosynthetic process from S-adenosylmethionine; IEA:HAMAP.
 GO:0019509; P:L-methionine salvage from methylthioadenosine; ISS:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
 GO:0070372; P:regulation of ERK1 and ERK2 cascade; IMP:UniProtKB. 

Interpro

 IPR001303; Aldolase_II/adducin_N.
 IPR017714; MethylthioRu-1-P_deHdtase_MtnB.
 IPR027514; Salvage_MtnB_euk. 

Pfam

 PF00596; Aldolase_II 

SMART

 SM01007; Aldolase_II 

PROSITE

  

PRINTS