| Tag | Content |
|---|
| CPLM ID | CPLM-007215 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein phosphatase 2C homolog 2 |
Protein Synonyms/Alias | PP2C-2 |
Gene Name | PTC2 |
Gene Synonyms/Alias | YER089C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 52 | NVLTKSDKDHIAFYG | ubiquitination | [1] | | 114 | LLQDPVMKEDHSGCT | ubiquitination | [1] | | 257 | HLGLREGKTLNEISS | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Responsible, together with PTC3, for the dephosphorylation of the cyclin-dependent protein kinase CDC28. |
Sequence Annotation | METAL 62 62 Manganese 1 (By similarity).
METAL 62 62 Manganese 2 (By similarity).
METAL 63 63 Manganese 1; via carbonyl oxygen (By
METAL 234 234 Manganese 2 (By similarity).
METAL 283 283 Manganese 2 (By similarity).
MOD_RES 376 376 Phosphothreonine.
MOD_RES 380 380 Phosphothreonine. |
Keyword | Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Phosphoprotein; Protein phosphatase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 464 AA |
Protein Sequence | MGQILSNPVI DKESHSGADS LTAFGLCAMQ GWRMSMEDSH ILEPNVLTKS DKDHIAFYGI 60
FDGHGGAKVA EYCGNKIVEI LQEQKSFHEG NLPRALIDTF INTDVKLLQD PVMKEDHSGC 120
TATSILVSKS QNLLVCGNAG DSRTVLATDG NAKALSYDHK PTLASEKSRI VAADGFVEMD 180
RVNGNLALSR AIGDFEFKSN PKLGPEEQIV TCVPDILEHS LDYDRDEFVI LACDGIWDCL 240
TSQDCVDLVH LGLREGKTLN EISSRIIDVC CAPTTEGTGI GCDNMSIVVV ALLKEGEDVA 300
QWSDRMKSKA HRTSVRSFAD KRRRVFSYYD FSKCNDEQVF AITTKKPQDK FTRDHEAAVA 360
SVTAADNDDP MDIDDTDADT DAENLDPSSQ SKSKTSGPID LASLEALLGA TGGVKTDSNG 420
NKVTYTLPQS ALAQLLQTMG HDPASSHPEN DSNTDHKAGR SHLQ 464 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:SGD. GO:0005634; C:nucleus; IDA:SGD. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004722; F:protein serine/threonine phosphatase activity; IDA:SGD. GO:0000077; P:DNA damage checkpoint; IGI:SGD. GO:0030968; P:endoplasmic reticulum unfolded protein response; IPI:SGD. GO:0000173; P:inactivation of MAPK activity involved in osmosensory signaling pathway; IGI:SGD. GO:0006470; P:protein dephosphorylation; IDA:SGD. GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IMP:SGD. |
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SMART | |
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PRINTS | |