UniProt Accession

 PEA15_HUMAN; Q15121; O00511 

Genbank Protein ID

 X86809; Y13736; AF153274; AF153273; BC002426; BC022554; BT007252 

Genbank Nucleotide ID

 CAA60499.1; CAA74076.1; AAD56775.1; AAD56775.1; AAH02426.1; AAH22554.1; AAP35916.1 

Protein Name

 Astrocytic phosphoprotein PEA-15 

Protein Synonyms/Alias

 15 kDa phosphoprotein enriched in astrocytes; Phosphoprotein enriched in diabetes; PED 

Gene Name

 PEA15 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
98	EEDELDTKLTRIPSA	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. 

Sequence Annotation

 DOMAIN 3 81 DED.
 REGION 98 107 Microtubule-binding (Potential).
 REGION 122 129 Microtubule-binding (Potential).
 MOD_RES 61 61 Phosphoserine.
 MOD_RES 104 104 Phosphoserine.
 MOD_RES 116 116 Phosphoserine.  

Keyword

 3D-structure; Apoptosis; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome; Sugar transport; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 130 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005875; C:microtubule associated complex; NAS:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
 GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IDA:UniProtKB.
 GO:0046325; P:negative regulation of glucose import; IDA:UniProtKB.
 GO:0043278; P:response to morphine; IEA:Compara.
 GO:0006810; P:transport; TAS:ProtInc. 

Interpro

 IPR011029; DEATH-like_dom.
 IPR001875; DED. 

Pfam

 PF01335; DED 

SMART

 SM00031; DED 

PROSITE

 PS50168; DED 

PRINTS