UniProt Accession

 FKBP8_MOUSE; O35465; Q3UK86; Q6GTX9; Q811M7; Q811R4; Q8C2F0; Q99L93 

Genbank Protein ID

 AY225340; AY278608; AK088739; AK146122; AK152198; AK165281; AK167663; BC003739; BC027808; AF030635; AY187231 

Genbank Nucleotide ID

 AAO39021.1; AAQ84562.1; BAC40541.1; BAE26916.1; BAE31027.1; BAE38118.1; BAE39713.1; AAH03739.1; AAH27808.1; AAB86422.1; AAO27795.1 

Protein Name

 Peptidyl-prolyl cis-trans isomerase FKBP8 

Protein Synonyms/Alias

 PPIase FKBP8; 38 kDa FK506-binding protein; 38 kDa FKBP; FKBP-38; mFKBP38; FK506-binding protein 8; FKBP-8; FKBPR38; Rotamase 

Gene Name

 Fkbp8 

Gene Synonyms/Alias

 Fkbp38; Sam11 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
102	KTLVPGPKGSSRPLK	ubiquitination	[1]
261	EEELLQLKVKCLNNL	ubiquitination	[1]
274	NLAASQLKLDHYRAA	ubiquitination	[1]
297	EHQPDNIKALFRKGK	ubiquitination	[1]
304	KALFRKGKVLAQQGE	ubiquitination	[1]
330	LKLEPSNKTIHAELS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). Required for normal embryonic development. 

Sequence Annotation

 DOMAIN 110 194 PPIase FKBP-type.
 REPEAT 211 244 TPR 1.
 REPEAT 262 295 TPR 2.
 REPEAT 296 329 TPR 3.  

Keyword

 Alternative splicing; Apoptosis; Calcium; Complete proteome; Isomerase; Membrane; Mitochondrion; Reference proteome; Repeat; Rotamase; TPR repeat; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 402 AA 

Protein Sequence

Gene Ontology

 GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:MGI.
 GO:0005740; C:mitochondrial envelope; IDA:MGI.
 GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
 GO:0005528; F:FK506 binding; IBA:RefGenome.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:RefGenome.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0043010; P:camera-type eye development; IMP:MGI.
 GO:0001708; P:cell fate specification; IMP:MGI.
 GO:0021904; P:dorsal/ventral neural tube patterning; IDA:MGI.
 GO:0035264; P:multicellular organism growth; IGI:MGI.
 GO:0030513; P:positive regulation of BMP signaling pathway; IMP:MGI.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0010468; P:regulation of gene expression; IGI:MGI.
 GO:0007224; P:smoothened signaling pathway; IMP:MGI. 

Interpro

 IPR023114; Elongated_TPR_rpt_dom.
 IPR023566; PPIase_FKBP.
 IPR001179; PPIase_FKBP_dom.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 

Pfam

 PF00254; FKBP_C
 PF00515; TPR_1 

SMART

  

PROSITE

 PS50059; FKBP_PPIASE
 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS