Tag | Content |
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CPLM ID | CPLM-010699 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Peroxisomal multifunctional enzyme type 2 |
Protein Synonyms/Alias | MFE-2; 17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; D-bifunctional protein; DBP; Multifunctional protein 2; MPF-2; (3R)-hydroxyacyl-CoA dehydrogenase; Enoyl-CoA hydratase 2; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase |
Gene Name | Hsd17b4 |
Gene Synonyms/Alias | Edh17b4 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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46 | NDLGGDFKGVGKGSS | acetylation | [1] | 57 | KGSSAADKVVEEIRR | acetylation | [1] | 81 | DSVEAGEKLVKTALD | acetylation | [1] | 84 | EAGEKLVKTALDTFG | acetylation | [1] | 139 | RAAWDHMKKQNYGRI | acetylation | [1] | 564 | AIKVRFAKPVYPGQT | acetylation | [1] | 578 | TLQTEMWKEGNRIHF | acetylation | [1] | 668 | AKWTIDLKNGSGEVY | acetylation | [1] | 730 | QKLQMILKDYAKL** | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids. |
Sequence Annotation | DOMAIN 483 599 MaoC-like. DOMAIN 623 735 SCP2. NP_BIND 16 40 NAD. NP_BIND 75 76 NAD (By similarity). NP_BIND 164 168 NAD (By similarity). NP_BIND 196 199 NAD (By similarity). REGION 2 305 (3R)-hydroxyacyl-CoA dehydrogenase. REGION 321 621 Enoyl-CoA hydratase 2. REGION 405 406 (3R)-3-hydroxydecanoyl-CoA binding (By REGION 509 514 (3R)-3-hydroxydecanoyl-CoA binding (By MOTIF 733 735 Microbody targeting signal (Potential). ACT_SITE 164 164 Proton acceptor. BINDING 21 21 NAD; via amide nitrogen (By similarity). BINDING 40 40 NAD (By similarity). BINDING 99 99 NAD; via carbonyl oxygen (By similarity). BINDING 151 151 Substrate. BINDING 434 434 (3R)-3-hydroxydecanoyl-CoA (By BINDING 532 532 (3R)-3-hydroxydecanoyl-CoA; via amide BINDING 562 562 (3R)-3-hydroxydecanoyl-CoA; via carbonyl BINDING 705 705 Substrate (By similarity). BINDING 723 723 Substrate (By similarity). MOD_RES 2 2 N-acetylalanine (By similarity). MOD_RES 3 3 Phosphoserine (By similarity). MOD_RES 304 304 Phosphoserine (By similarity). MOD_RES 308 308 Phosphoserine (By similarity). MOD_RES 564 564 N6-acetyllysine (By similarity). MOD_RES 662 662 N6-acetyllysine (By similarity). MOD_RES 668 668 N6-acetyllysine (By similarity). |
Keyword | 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Fatty acid metabolism; Isomerase; Lipid metabolism; Lyase; NAD; Oxidoreductase; Peroxisome; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 735 AA |
Protein Sequence | MASPLRFDGR VVLVTGAGGG LGRAYALAFA ERGALVVVND LGGDFKGVGK GSSAADKVVE 60 EIRRRGGKAV ANYDSVEAGE KLVKTALDTF GRIDVVVNNA GILRDRSFSR ISDEDWDIIQ 120 RVHLRGSFQV TRAAWDHMKK QNYGRIIMTA SASGIYGNFG QANYSAAKLG LLGLANTLVI 180 EGRKNNIHCN TIAPNAGSRM TETVMPEDLV EALKPEYVAP LVLWLCHESC EENGGLFEVG 240 AGWIGKLRWE RTLGAIVRKR NQPMTPEAVR DNWVKICDFS NASKPKSIQE STGGIIEVLH 300 KIDSEGISQN HTGQVASADA SGFAGVVGHK LPSFSSSYTE LQCIMYALGV GASVKNPKDL 360 KFVYEGSADF SCLPTFGVIV AQKSLMSGGL AEVPGLSINF AKVLHGEQYL ELYKPLPRSG 420 ELKCEAVIAD ILDKGSGIVI VMDVYSYSGK ELICYNQFSV FVVGSGGFGG KRTSEKLKAA 480 VAVPSRPPDA VLRDTTSLNQ AALYRLSGDS NPLHIDPSFA SIAGFEKPIL HGLCTFGFSA 540 RHVLQQFADN DVSRFKAIKV RFAKPVYPGQ TLQTEMWKEG NRIHFQTKVQ ETGDIVISNA 600 YVDLVPTSGV SAQTPSEGGA LQSALVFGEI GRRLKDVGRE VVKKVNAVFE WHITKNGNVA 660 AKWTIDLKNG SGEVYQGPAK GSADTTITIS DEDFMEVVLG KLNPQNAFFS GRLKARGNIM 720 LSQKLQMILK DYAKL 735 |
Gene Ontology | GO:0005739; C:mitochondrion; IEA:Compara. GO:0005777; C:peroxisome; IDA:HGNC. GO:0033989; F:3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity; IEA:EC. GO:0016853; F:isomerase activity; IEA:UniProtKB-KW. GO:0032934; F:sterol binding; IEA:InterPro. GO:0030283; F:testosterone dehydrogenase [NAD(P)] activity; TAS:RGD. GO:0008203; P:cholesterol metabolic process; NAS:RGD. GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway. GO:0060009; P:Sertoli cell development; IEA:Compara. GO:0000038; P:very long-chain fatty acid metabolic process; IEA:Compara. |
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