UniProt Accession

 D3ZLY9_RAT; D3ZLY9 

Genbank Protein ID

 AABR06092171; CH474072 

Genbank Nucleotide ID

 EDL84587.1 

Protein Name

 Histone H2B 

Protein Synonyms/Alias

  

Gene Name

 Hist1h2bl 

Gene Synonyms/Alias

 Hist1h2bf; rCG_23123 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
6	**MPEPAKSVPAPKK	acetylation	[1]
12	AKSVPAPKKGSKKAV	acetylation	[1]
13	KSVPAPKKGSKKAVT	acetylation	[1]
16	PAPKKGSKKAVTKAQ	acetylation	[1]
17	APKKGSKKAVTKAQK	acetylation	[1]
21	GSKKAVTKAQKKDGK	acetylation	[1]
24	KAVTKAQKKDGKKRK	acetylation	[1]
35	KKRKRSRKESYSVYV	acetylation	[1]
44	SYSVYVYKVLKQVHP	acetylation	[1]
47	VYVYKVLKQVHPDTG	acetylation	[1]
47	VYVYKVLKQVHPDTG	ubiquitination	[2]
86	SRLAHYNKRSTITSR	acetylation	[1]
109	LLPGELAKHAVSEGT	acetylation	[1]
109	LLPGELAKHAVSEGT	ubiquitination	[2]
117	HAVSEGTKAVTKYTS	acetylation	[1]
117	HAVSEGTKAVTKYTS	ubiquitination	[2]
121	EGTKAVTKYTSSK**	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). 

Sequence Annotation

  

Keyword

 Chromosome; Complete proteome; DNA-binding; Isopeptide bond; Nucleosome core; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 126 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR000558; Histone_H2B. 

Pfam

 PF00125; Histone 

SMART

 SM00427; H2B 

PROSITE

 PS00357; HISTONE_H2B 

PRINTS

 PR00621; HISTONEH2B.