CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018409
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 tRNA pseudouridine synthase D 
Protein Synonyms/Alias
 tRNA pseudouridine(13) synthase; tRNA pseudouridylate synthase D; tRNA-uridine isomerase D 
Gene Name
 truD 
Gene Synonyms/Alias
 STM2928 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
50HILLRILKNGCNTRFacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity). 
Sequence Annotation
 DOMAIN 155 303 TRUD.
 ACT_SITE 80 80 Nucleophile (By similarity).
 BINDING 27 27 Substrate (By similarity).
 BINDING 129 129 Substrate (By similarity).
 BINDING 329 329 Substrate (By similarity).  
Keyword
 Complete proteome; Isomerase; Reference proteome; tRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 349 AA 
Protein Sequence
MTEFDNLTWL HGKPQGSGLL KANPEDFVVV EDLGFTPDGE GEHILLRILK NGCNTRFVAD 60
ALAKFLKIHA REVSFAGQKD KHAVTEQWLC ARVPGKEMPD FSAFQLEGCK VLEYARHKRK 120
LRLGALKGNA FTLVLREISD RRDVETRLQA IRDGGVPNYF GAQRFGIGGS NLQGALRWAQ 180
SNAPVRDRNK RSFWLSAARS ALFNQIVHQR LKKPDFNQVV DGDALQLAGR GSWFVATSEE 240
LPELQRRVDE KELMITASLP GSGEWGTQRA ALAFEQDAIA QETVLQSLLL REKVEASRRA 300
MLLYPQQLSW NWWDDVTVEL RFWLPAGSFA TSVVRELINT MGDYAHIAE 349 
Gene Ontology
 GO:0009982; F:pseudouridine synthase activity; IEA:HAMAP.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0031119; P:tRNA pseudouridine synthesis; IEA:HAMAP. 
Interpro
 IPR020103; PsdUridine_synth_cat_dom.
 IPR001656; PsdUridine_synth_TruD.
 IPR020119; PsdUridine_synth_TruD_CS.
 IPR011760; PsdUridine_synth_TruD_insert. 
Pfam
 PF01142; TruD 
SMART
  
PROSITE
 PS50984; TRUD
 PS01268; UPF0024 
PRINTS